Photoelectrochemical Iron(III) Catalysis for Late‐Stage C─H Fluoroalkylations
Abstract
Abstract Chemo‐ and site‐selective functionalization of complex molecules poses a fundamental challenge. Herein, we introduce a resource‐economic photoelectrocatalysis strategy to enable versatile direct fluoroalkylations catalyzed by Earth‐abundant iron and paired with the hydrogen evolution reaction (HER). Notably, the devised approach proved amenable to versatile late‐stage C─H fluoroalkylations of bio‐relevant heterocycles, such as xanthines, nucleobases, and nucleosides. Mechanistic studies supported a ligand‐to‐metal charge transfer‐induced formation of the fluoroalkyl radical.
Article Details
Authors (9)
Vladimir Motornov
Wöhler Research Institute for Sustainable Chemistry (WISCh) Georg‐August‐Universität Tammannstraße 2 37077 Göttingen Germany
Sven Trienes
Wöhler Research Institute for Sustainable Chemistry (WISCh) Georg‐August‐Universität Göttingen Tammannstraße 2 37077 Göttingen Germany
Simonetta Resta
Wöhler Research Institute for Sustainable Chemistry (WISCh) Georg‐August‐Universität Tammannstraße 2 37077 Göttingen Germany
João C. A. Oliveira
Wöhler Research Institute for Sustainable Chemistry
Zhipeng Lin
Zhi Liu
Laboratory of Atmospheric Environment and Pollution Control
Tristan von Münchow
University of Bologna, Department of Industrial Chemistry Toso Montanari, via Piero Gobetti 85, 40129 Bologna, Italy
Claudia Stückl
Institut für Anorganische Chemie Georg‐August‐Universität Tammannstraße 4 37077 Göttingen Germany
Lutz Ackermann
Institut für Organische und Biomolekulare Chemie (IOBC)