Photobiocatalytic Radical Hydroalkylation with C(sp
                    <sup>3</sup>
                    )–H Bonds Enabled by Engineered Imine Reductase and Redox Buffering

Bin Chen; Ran Ge; Jinhai Yu; Ruiqi Zhu; Qin Zhu; Jiawei Zhang; Mingfeng Cao; Xiaoqiang Huang

doi:10.1021/jacs.5c10377

Journal of the American Chemical Society

Photobiocatalytic Radical Hydroalkylation with C(sp <sup>3</sup> )–H Bonds Enabled by Engineered Imine Reductase and Redox Buffering

B Bin Chen R Ran Ge (Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Key Laboratory for Synthetic Biotechnology of Xiamen City) J Jinhai Yu (State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), Frontier Interdisciplinary Science Research Center, School of Chemistry and Chemical Engineering) R Ruiqi Zhu (State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), Frontier Interdisciplinary Science Research Center, School of Chemistry and Chemical Engineering) Q Qin Zhu J Jiawei Zhang M Mingfeng Cao (Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Key Laboratory for Synthetic Biotechnology of Xiamen City) X Xiaoqiang Huang

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Article Details

Journal Journal of the American Chemical Society

Volume / Issue Vol. 147, Issue 42

Published October 22, 2025

Pages 38195-38203

DOI 10.1021/jacs.5c10377

ISSN 0002-7863

Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

B

Bin Chen

R

Ran Ge

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Key Laboratory for Synthetic Biotechnology of Xiamen City

J

Jinhai Yu

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), Frontier Interdisciplinary Science Research Center, School of Chemistry and Chemical Engineering

R

Ruiqi Zhu

State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), Frontier Interdisciplinary Science Research Center, School of Chemistry and Chemical Engineering

Q

Qin Zhu

J

Jiawei Zhang

M

Mingfeng Cao

Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Key Laboratory for Synthetic Biotechnology of Xiamen City

X

Xiaoqiang Huang

Photobiocatalytic Radical Hydroalkylation with C(sp <sup>3</sup> )–H Bonds Enabled by Engineered Imine Reductase and Redox Buffering

Article Details

Journal Info

Authors (8)

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