Phosphine‐Catalyzed Enantioselective [2 + 2] Annulations of <i>α</i> ‐Allyl <i>γ</i> ‐Benzyl Allenoates via a Transannular Cyclization Approach
Abstract
Abstract Fused cyclobutane frameworks are valuable scaffolds in natural products and pharmaceuticals, yet catalytic asymmetric methods for their construction remain rare due to ring strain and stereocontrol challenges. Here, we report a spiro phosphine‐catalyzed, stereoconvergent, and enantioselective [2 + 2] annulation of racemic α ‐allyl γ ‐benzyl allenoates via transannular cyclization, efficiently delivering bicyclo[3.2.0]heptenes in high yields and excellent enantioselectivity. Experimental studies and DFT calculations indicate a stepwise mechanism involving seven‐membered zwitterion formation, dynamic kinetic resolution through reversible nucleophilic addition, and a rate‐ and enantioselectivity‐determining deprotonation via intramolecular hydrogen transfer. This protocol offers a concise and general approach to enantioenriched fused cyclobutanes, expanding synthetic options for drug discovery.
Article Details
Authors (5)
Xu‐Ling Pan
State Key Laboratory and Institute of Elemento‐Organic Chemistry College of Chemistry Frontiers Science Center for New Organic Matter Nankai University Tianjin 300071 China
Wei‐Guo Xiao
State Key Laboratory and Institute of Elemento‐Organic Chemistry College of Chemistry Frontiers Science Center For New Organic Matter Nankai University Tianjin China
Li‐Jun Xiao
State Key Laboratory and Institute of Elemento‐Organic Chemistry College of Chemistry Frontiers Science Center For New Organic Matter Nankai University Tianjin China
Qi‐Lin Zhou
State Key Laboratory and Institute of Elemento‐Organic Chemistry College of Chemistry, Frontiers Science Center for New Organic Matter Nankai University Tianjin China
You Huang