Phase 3 Results of Bepirovirsen Treatment for Chronic Hepatitis B Virus Infection

J Jinlin Hou (Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangzhou, China) S Seng-Gee Lim (Division of Gastroenterology and Hepatology, National University Health System, Singapore) M María Buti M Man-Fung Yuen E Edward Gane (Liver Transplant Unit, University of Auckland, Auckland, New Zealand) P Pietro Lampertico (Division of Gastroenterology and Hepatology, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan) N Norah Terrault (Gastrointestinal and Liver Diseases Division, Keck School of Medicine, University of Southern California, Los Angeles) H Huy Nguyen (Department of Chemical Engineering and Materials Science) H Hyung Joon Yim Q Qing Xie J Jianmei Lin (Department of Infectious Disease, Sichuan Provincial People’s Hospital, Chengdu, China) Y Yunqing Qiu (Department of Infectious Disease, 1st Affiliated Hospital of Zhejiang University, Hangzhou, China) W Wen-Juei Jeng (Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan) J Jeong Heo C Cheng-Yuan Peng (Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan) C Chien-Hung Chen W Wan-Long Chuang (Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan) Y Yao Xie M Maria Hlebowicz (Department of Family Medicine and Infectious Diseases, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland) N Nevin Idriz (Clinic of Internal Diseases and Hepato-Gastroenterology, University of Medicine and Hospital for Active Treatment Sofiamed, Sofia, Bulgaria) R Rajiv Mehta (Department of Gastroenterology, SIDS Hospital and Research Center, Surat, India) K Kosh Agarwal (Institute of Liver Studies, Kings College Hospital NHS Trust, London) M Monica M. Gomes da Silva (Department of Public Health, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil) A Alex Franca (Hospital de Cirurgia, NewData Clinical Research, Federal University of Sergipe, Aracaju, Brazil) R Roxana Cernat (Research Unit, Clinical Hospital for Infectious Diseases, Ovidius University of Constanta, Constanta, Romania) A Apinya Leerapun (Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand) C Carla S. Coffin (Department of Medicine, Snyder Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada) A Adrian Gadano (Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires) P Pietro Andreone (Medicina Interna a Indirizzo Metabolico-Nutrizionale, Ospedale Clinicizzato di Baggiovara, Azienda Ospedaliaro–Universitaria di Modena, Modena, Italy) S Shigetoshi Fujiyama (Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital, Kumamoto, Japan) V Vasileios Sevastianos (3rd Department of Internal Medicine and Liver Unit, Evangelismos General Hospital, Athens) Y Yuichiro Suzuki (Department of Biological Sciences, Wellesley College) V Vlad Ratziu (Sorbonne Université, Hôpital Pitié–Salpêtrière, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris) G Ghassan Riachi (Centre Hospitalier Universitaire de Rouen, Hôpital Charles Nicolle, Rouen, France) H Hartmut Stocker (Epimed, Berlin) T Tien Huey Lim (Aotearoa Clinical Trials, Papatoetoe, Auckland, New Zealand) T Tarik Asselah (Université de Paris-Cité, INSERM Unité Mixte de Recherche 1149, Paris) Y Yasuhito Tanaka (Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University) J Jacinta Holmes (Department of Gastroenterology, St. Vincent’s Hospital Melbourne, University of Melbourne, Fitzroy, VIC, Australia) X Xieer Liang (Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangzhou, China) J Jennifer Cremer (GSK, Durham, NC) T Tamara Lukić (GSK, Dubai, United Arab Emirates) H Helene Plein (GSK, London) G Geoff Quinn (GSK, Stevenage, United Kingdom) Y Yu Tao M Melanie Paff (GSK, Collegeville, PA) D Dickens Theodore (GSK, Durham, NC) R Robert Elston (GSK, Stevenage, United Kingdom)

Article Details

Volume / Issue Vol. 394, Issue 24
Published June 25, 2026
Pages 2395-2406
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (48)

J

Jinlin Hou

Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangzhou, China

S

Seng-Gee Lim

Division of Gastroenterology and Hepatology, National University Health System, Singapore

M

María Buti

M

Man-Fung Yuen

E

Edward Gane

Liver Transplant Unit, University of Auckland, Auckland, New Zealand

P

Pietro Lampertico

Division of Gastroenterology and Hepatology, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan

N

Norah Terrault

Gastrointestinal and Liver Diseases Division, Keck School of Medicine, University of Southern California, Los Angeles

H

Huy Nguyen

Department of Chemical Engineering and Materials Science

H

Hyung Joon Yim

Q

Qing Xie

J

Jianmei Lin

Department of Infectious Disease, Sichuan Provincial People’s Hospital, Chengdu, China

Y

Yunqing Qiu

Department of Infectious Disease, 1st Affiliated Hospital of Zhejiang University, Hangzhou, China

W

Wen-Juei Jeng

Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taiwan

J

Jeong Heo

C

Cheng-Yuan Peng

Center for Digestive Medicine, Department of Internal Medicine, China Medical University Hospital, China Medical University, Taichung, Taiwan

C

Chien-Hung Chen

W

Wan-Long Chuang

Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

Y

Yao Xie

M

Maria Hlebowicz

Department of Family Medicine and Infectious Diseases, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland

N

Nevin Idriz

Clinic of Internal Diseases and Hepato-Gastroenterology, University of Medicine and Hospital for Active Treatment Sofiamed, Sofia, Bulgaria

R

Rajiv Mehta

Department of Gastroenterology, SIDS Hospital and Research Center, Surat, India

K

Kosh Agarwal

Institute of Liver Studies, Kings College Hospital NHS Trust, London

M

Monica M. Gomes da Silva

Department of Public Health, Hospital de Clínicas, Federal University of Paraná, Curitiba, Brazil

A

Alex Franca

Hospital de Cirurgia, NewData Clinical Research, Federal University of Sergipe, Aracaju, Brazil

R

Roxana Cernat

Research Unit, Clinical Hospital for Infectious Diseases, Ovidius University of Constanta, Constanta, Romania

A

Apinya Leerapun

Department of Internal Medicine, Chiang Mai University, Chiang Mai, Thailand

C

Carla S. Coffin

Department of Medicine, Snyder Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada

A

Adrian Gadano

Liver Unit, Hospital Italiano de Buenos Aires, Buenos Aires

P

Pietro Andreone

Medicina Interna a Indirizzo Metabolico-Nutrizionale, Ospedale Clinicizzato di Baggiovara, Azienda Ospedaliaro–Universitaria di Modena, Modena, Italy

S

Shigetoshi Fujiyama

Department of Gastroenterology and Hepatology, Kumamoto Shinto General Hospital, Kumamoto, Japan

V

Vasileios Sevastianos

3rd Department of Internal Medicine and Liver Unit, Evangelismos General Hospital, Athens

Y

Yuichiro Suzuki

Department of Biological Sciences, Wellesley College

V

Vlad Ratziu

Sorbonne Université, Hôpital Pitié–Salpêtrière, Assistance Publique–Hôpitaux de Paris (AP-HP), Paris

G

Ghassan Riachi

Centre Hospitalier Universitaire de Rouen, Hôpital Charles Nicolle, Rouen, France

H

Hartmut Stocker

Epimed, Berlin

T

Tien Huey Lim

Aotearoa Clinical Trials, Papatoetoe, Auckland, New Zealand

T

Tarik Asselah

Université de Paris-Cité, INSERM Unité Mixte de Recherche 1149, Paris

Y

Yasuhito Tanaka

Department of Gastroenterology and Hepatology, Faculty of Life Sciences, Kumamoto University

J

Jacinta Holmes

Department of Gastroenterology, St. Vincent’s Hospital Melbourne, University of Melbourne, Fitzroy, VIC, Australia

X

Xieer Liang

Department of Infectious Diseases, Nanfang Hospital, Southern Medical University, State Key Laboratory of Multi-organ Injury Prevention and Treatment, Key Laboratory of Infectious Diseases Research in South China, Ministry of Education, Guangzhou, China

J

Jennifer Cremer

GSK, Durham, NC

T

Tamara Lukić

GSK, Dubai, United Arab Emirates

H

Helene Plein

GSK, London

G

Geoff Quinn

GSK, Stevenage, United Kingdom

Y

Yu Tao

M

Melanie Paff

GSK, Collegeville, PA

D

Dickens Theodore

GSK, Durham, NC

R

Robert Elston

GSK, Stevenage, United Kingdom