Phase 1 Study of Rezatapopt, a p53 Reactivator, in
                    <i>TP53</i>
                    Y220C–Mutated Tumors

Ecaterina E. Dumbrava; Geoffrey I. Shapiro; Aparna R. Parikh; Melissa L. Johnson; Anthony W. Tolcher; John A. Thompson; Anthony B. El-Khoueiry; Andrae L. Vandross; Shivaani Kummar; Dale R. Shepard; Kim LeDuke; Lisa Sheehan; Leila Alland; Arshad Haque; Deepika Jalota; Marc Fellous; Alison M. Schram

doi:10.1056/nejmoa2508820

Phase 1 Study of Rezatapopt, a p53 Reactivator, in <i>TP53</i> Y220C–Mutated Tumors

E Ecaterina E. Dumbrava (University of Texas M.D. Anderson Cancer Center, Houston) G Geoffrey I. Shapiro A Aparna R. Parikh (Massachusetts General Hospital, Boston) M Melissa L. Johnson A Anthony W. Tolcher (NEXT Oncology, San Antonio, TX) J John A. Thompson A Anthony B. El-Khoueiry (University of Southern California Norris Comprehensive Cancer Center, Los Angeles) A Andrae L. Vandross (NEXT Oncology, Austin, Texas) S Shivaani Kummar D Dale R. Shepard (Cleveland Clinic Foundation, Cleveland) K Kim LeDuke (PMV Pharmaceuticals, Princeton, NJ) L Lisa Sheehan (PMV Pharmaceuticals, Princeton, NJ) L Leila Alland (Leila Alland MD Consultancy, New York) A Arshad Haque (PMV Pharmaceuticals, Princeton, NJ) D Deepika Jalota (PMV Pharmaceuticals, Princeton, NJ) M Marc Fellous (PMV Pharmaceuticals, Princeton, NJ) A Alison M. Schram (Memorial Sloan Kettering Cancer Center, New York)

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Article Details

Journal New England Journal of Medicine

Volume / Issue Vol. 394, Issue 9

Published February 26, 2026

Pages 872-883

DOI 10.1056/nejmoa2508820

ISSN 0028-4793

Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (17)

E

Ecaterina E. Dumbrava

University of Texas M.D. Anderson Cancer Center, Houston

G

Geoffrey I. Shapiro

A

Aparna R. Parikh

Massachusetts General Hospital, Boston

M

Melissa L. Johnson

A

Anthony W. Tolcher

NEXT Oncology, San Antonio, TX

J

John A. Thompson

A

Anthony B. El-Khoueiry

University of Southern California Norris Comprehensive Cancer Center, Los Angeles

A

Andrae L. Vandross

NEXT Oncology, Austin, Texas

S

Shivaani Kummar

D

Dale R. Shepard

Cleveland Clinic Foundation, Cleveland

K

Kim LeDuke