Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice

Alessia Angelin; Kierstin Keller; Peiran Lu; Joseph W. Guarnieri; Gabrielle A. Widjaja; Rasheed Sule; Kevin Janssen; Arnold Olali; Zimu Cen; Valeria Carosi; Maina Beauplan; Deborah G. Murdock; Prasanth Potluri; Liming Pei; Douglas C. Wallace

doi:10.1038/s41467-025-67134-4

Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice

A Alessia Angelin K Kierstin Keller (Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia) P Peiran Lu J Joseph W. Guarnieri G Gabrielle A. Widjaja R Rasheed Sule K Kevin Janssen A Arnold Olali Z Zimu Cen V Valeria Carosi M Maina Beauplan (Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia) D Deborah G. Murdock (Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia) P Prasanth Potluri L Liming Pei D Douglas C. Wallace

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Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published December 15, 2025

DOI 10.1038/s41467-025-67134-4

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (15)

A

Alessia Angelin

K

Kierstin Keller

Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia

P

Peiran Lu

J

Joseph W. Guarnieri

G

Gabrielle A. Widjaja

R

Rasheed Sule

K

Kevin Janssen

A

Arnold Olali

Z

Zimu Cen

V

Valeria Carosi

M

Maina Beauplan

Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia

D

Deborah G. Murdock

Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia

P

Prasanth Potluri

L

Liming Pei

D

Douglas C. Wallace

Partial restoration of mitochondrial dysfunction by AAV-Ant1 protects from dilated cardiomyopathy in Ant1-/- plus mtDNA mutant mice

Article Details

Journal Info

Authors (15)

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