Paraneoplastic syndromes in non-small cell lung carcinoma: A systematic review of case reports and case series.

Abstract

e20041 Background: Paraneoplastic syndromes (PNS) are caused by underlying malignancy but not due to metastasis, or treatment related side effects. Studies are lacking which target PNS seen in non small cell lung cancer (NSCLC) Methods: Systematic search of PubMed & Scopus was conducted to include all case reports & case series of adult NSCLC patients with PNS, published globally from inception upto July 7, 2024. Patient demographics, geographical distribution, NSCLC histology, clinical manifestations, diagnosis, treatment was extracted. Quality was assessed by JBI's critical appraisal checklist. Results: 138 publications (136 case reports, 2 case series) describing 142 patients published in 30 countries were included. Majority patients were male (69.7%) with mean age 57 years. Top publishing countries were USA (28.2%), Japan (13%), China (6.5%), Germany (5%), with publications (n=16) peak seen in 2020. Histological type of NSCLC with PNS was adenocarcinoma (39.8%), SCC (26.8%), unspecified histology (13%) & large cell (8.6%). Most common PNS seen in NSCLC were hypertrophic osteoarthropathy (7.2%), bilateral diffuse uveal melanocytic proliferation (5.7%), leukemoid reaction (4.3%) & limbic encephalitis (4.3%). Conclusions: Study provides bird’s eye view of all PNS found in NSCLC, aiding in timely diagnosis & treatment of NSCLC. Organ system PNS Cases Neurology Limbic encephalitisOpsoclonus myoclonus syndromeGBSSensorimotor peripheral neuropathyCerebellar degenerationEncephalomyelitisPerson in barrel syndromeMyoclonusPandysautonomiaNeuromyelitis opticaOpsoclonusAntiHu Ab neuropathyMononeuritis multiplexMorvan syndrome 63221111111111 Cardiology & haematology Leukemoid reactionLeukocytoclastic vasculitisHSPDICITPMyelofibrosisAcral vascular cyanosisHyper eosinophiliaHeart blockTrousseau syndromeHaemophilia ASVC syndromeChurg Strauss syndrome 6332211111111 Endocrinology SIADHCushing syndromeHypercalcemia of malignancyGynaecomastiaβ HCG secretionErectile dysfunction 433221 Rheumatology Hypertrophic osteoarthropathyPolyarthritisPolymyositisDermatomyositisMyasthenia gravisLambert Eaton syndromePolymyalgia rheumaticaSclerodermaRaynaud phenomenonAnti synthetase syndrome 10433311111 Dermatology Bazex syndromeBullous pemphigoidErythema gyratumLeser Trélat Tripe palmsErythrodermaIchthyosisAcanthosis nigricansRhinophymaGranuloma annularePityriasis rubria pilarisEczemaErythema induratumHyperhidrosis 42212111111111 Ophthalmology Bilateral diffuse uveal melanocytic proliferationCancer associated retinopathyCicatrizing conjunctivitisRetinal detachmentOrbital inflammationOcular flutterProptosis 8311111 Nephrology Nephrotic syndrome 3 Gastroenterology Pseudo achalasiaVerner Morrison syndromeGranulomatous visceral neuronopathy 111 Musculoskeletal Necrotizing myopathy 2