Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

Victoria Roulstone; Joan Kyula-Currie; James Wright; Emmanuel C. Patin; Isaac Dean; Lu Yu; Aida Barreiro-Alonso; Miriam Melake; Jyoti Choudhary; Richard Elliott; Christopher J. Lord; David Mansfield; Nik Matthews; Ritika Chauhan; Victoria Jennings; Charleen Chan Wah Hak; Holly Baldock; Francesca Butera; Elizabeth Appleton; Pablo Nenclares; Malin Pedersen; Shane Foo; Amarin Wongariyapak; Antonio Rullan; Tencho Tenev; Pascal Meier; Richard Vile; Hardev Pandha; Alan Melcher; Martin McLaughlin; Kevin J. Harrington

doi:10.1038/s41467-025-60133-5

Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

V Victoria Roulstone J Joan Kyula-Currie J James Wright E Emmanuel C. Patin I Isaac Dean L Lu Yu A Aida Barreiro-Alonso M Miriam Melake J Jyoti Choudhary R Richard Elliott C Christopher J. Lord D David Mansfield N Nik Matthews R Ritika Chauhan V Victoria Jennings C Charleen Chan Wah Hak H Holly Baldock F Francesca Butera E Elizabeth Appleton P Pablo Nenclares M Malin Pedersen S Shane Foo A Amarin Wongariyapak A Antonio Rullan T Tencho Tenev P Pascal Meier R Richard Vile H Hardev Pandha A Alan Melcher M Martin McLaughlin K Kevin J. Harrington (Institute of Cancer Research, Royal Marsden Hospital, London)

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published May 25, 2025

DOI 10.1038/s41467-025-60133-5

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (31)

V

Victoria Roulstone

J

Joan Kyula-Currie

J

James Wright

E

Emmanuel C. Patin

I

Isaac Dean

L

Lu Yu

A

Aida Barreiro-Alonso

M

Miriam Melake

J

Jyoti Choudhary

R

Richard Elliott

C

Christopher J. Lord

D

David Mansfield

N

Nik Matthews

R

Ritika Chauhan

V

Victoria Jennings

C

Charleen Chan Wah Hak

H

Holly Baldock

F

Francesca Butera

E

Elizabeth Appleton

P

Pablo Nenclares

M

Malin Pedersen

S

Shane Foo

A

Amarin Wongariyapak

A

Antonio Rullan

T

Tencho Tenev

P

Pascal Meier

R

Richard Vile

H

Hardev Pandha

A

Alan Melcher

M

Martin McLaughlin

K

Kevin J. Harrington

Institute of Cancer Research, Royal Marsden Hospital, London

Palbociclib and dsRNA sensor co-operate to enhance anti-cancer effects through ER stress and modulation of immune evasion

Article Details

Journal Info

Authors (31)

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