P450-Mediated Dual Cyclization Mechanisms for Pyrroloindoline Unit Formation in Bispyrrolidinoindoline Diketopiperazine Alkaloid Biosynthesis

Y Yeqing Du (State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology) G Guangzheng Wei (State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology) T Tai-Ping Zhou (State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering) Y Yuhan Dai (State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology) W Wenya Tian (State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology) M Mancheng Tang (State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology) Z Zixin Deng B Binju Wang (State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering) X Xudong Qu (State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology)

Article Details

Volume / Issue Vol. 147, Issue 49
Published December 10, 2025
Pages 45199-45209
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (9)

Y

Yeqing Du

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology

G

Guangzheng Wei

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology

T

Tai-Ping Zhou

State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering

Y

Yuhan Dai

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology

W

Wenya Tian

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology

M

Mancheng Tang

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology

Z

Zixin Deng

B

Binju Wang

State Key Laboratory of Physical Chemistry of Solid Surfaces and Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering

X

Xudong Qu

State Key Laboratory of Microbial Metabolism and School of Life Sciences and Biotechnology