Overcoming the Hydrolytic Susceptibility of Thiol-Reactive Reversible Warheads through the Development of Substituted Phenyl Cyanoacrylamides

M Monessha Nambiar (Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health) Y Yixin Xie (Department of Chemistry and Biochemistry) J Joseph Ivanic (Advanced Biomedical Computational Science) J Joel P. Schneider (Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health)

Article Details

Volume / Issue Vol. 147, Issue 27
Published July 09, 2025
Pages 24140-24151
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (4)

M

Monessha Nambiar

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health

Y

Yixin Xie

Department of Chemistry and Biochemistry

J

Joseph Ivanic

Advanced Biomedical Computational Science

J

Joel P. Schneider

Chemical Biology Laboratory, Center for Cancer Research, National Cancer Institute, National Institutes of Health