Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

Yves Dauvilliers; Giuseppe Plazzi; Emmanuel Mignot; Gert Jan Lammers; Rafael del Río Villegas; Ramin Khatami; Mitsutaka Taniguchi; Anson Abraham; Yaming Hang; Harisha Kadali; Marta Lamberton; Sarah Sheikh; Ellie Stukalin; Rachel Neuwirth; Todd J. Swick; Shinichiro Tanaka; Christian von Hehn; Philipp von Rosenstiel; Hao Wang; Alice Cai; Melissa Naylor; Tina Olsson

doi:10.1056/nejmoa2405847

Oveporexton, an Oral Orexin Receptor 2–Selective Agonist, in Narcolepsy Type 1

Y Yves Dauvilliers (National Reference Network for Narcolepsy, Sleep and Wake Disorders Center, Department of Neurology, Gui de Chauliac Hospital, Montpellier, France) G Giuseppe Plazzi (Istituto di Ricovero e Cura a Carattere Scientifico - IRCCS Institute of Neurological Sciences) E Emmanuel Mignot (Stanford Center for Sleep Sciences and Medicine, Redwood City, CA) G Gert Jan Lammers (Sleep–Wake Center, Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands) R Rafael del Río Villegas (Neurophysiology and Sleep Disorders Unit, Vithas Hospitals, Madrid) R Ramin Khatami (Center of Sleep Medicine and Sleep Research, Klinik Barmelweid, Barmelweid, Switzerland) M Mitsutaka Taniguchi (Sleep Medical Center, Osaka Kaisei Hospital, Osaka, Japan) A Anson Abraham (Takeda Development Center Americas, Cambridge, MA) Y Yaming Hang (Takeda Development Center Americas, Cambridge, MA) H Harisha Kadali (Takeda Development Center Americas, Cambridge, MA) M Marta Lamberton (Takeda Development Center Americas, Cambridge, MA) S Sarah Sheikh (Takeda Development Center Americas, Cambridge, MA) E Ellie Stukalin (Takeda Development Center Americas, Cambridge, MA) R Rachel Neuwirth (Takeda Development Center Americas, Cambridge, MA) T Todd J. Swick (Takeda Development Center Americas, Cambridge, MA) S Shinichiro Tanaka (Takeda Development Center Americas, Cambridge, MA) C Christian von Hehn (Takeda Development Center Americas, Cambridge, MA) P Philipp von Rosenstiel (Takeda Development Center Americas, Cambridge, MA) H Hao Wang (Division of Quantitative Sciences, Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland USA) A Alice Cai (Takeda Development Center Americas, Cambridge, MA) M Melissa Naylor (Takeda Development Center Americas, Cambridge, MA) T Tina Olsson (Takeda Development Center Americas, Cambridge, MA)

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Article Details

Journal New England Journal of Medicine

Volume / Issue Vol. 392, Issue 19

Published May 15, 2025

Pages 1905-1916

DOI 10.1056/nejmoa2405847

ISSN 0028-4793

Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (22)

Y

Yves Dauvilliers

National Reference Network for Narcolepsy, Sleep and Wake Disorders Center, Department of Neurology, Gui de Chauliac Hospital, Montpellier, France

G

Giuseppe Plazzi

Istituto di Ricovero e Cura a Carattere Scientifico - IRCCS Institute of Neurological Sciences

E

Emmanuel Mignot

Stanford Center for Sleep Sciences and Medicine, Redwood City, CA

G

Gert Jan Lammers

Sleep–Wake Center, Stichting Epilepsie Instellingen Nederland, Heemstede, the Netherlands

R

Rafael del Río Villegas

Neurophysiology and Sleep Disorders Unit, Vithas Hospitals, Madrid

R

Ramin Khatami

Center of Sleep Medicine and Sleep Research, Klinik Barmelweid, Barmelweid, Switzerland

M

Mitsutaka Taniguchi

Sleep Medical Center, Osaka Kaisei Hospital, Osaka, Japan

A

Anson Abraham