Organic geochemical evidence for life in Archean rocks identified by pyrolysis–GC–MS and supervised machine learning

M Michael L. Wong A Anirudh Prabhu (Earth and Planets Laboratory, Carnegie Institution for Science) C Conel O’D. Alexander (Earth and Planets Laboratory, Carnegie Institution for Science) H H. James Cleaves (Earth and Planets Laboratory, Carnegie Institution for Science) G George D. Cody (Earth and Planets Laboratory, Carnegie Institution for Science) G Grethe Hystad (Department of Mathematics and Statistics, Purdue University Northwest) M Marko Bermanec (Department of Earth Sciences, University of Graz) W Wouter Bleeker (Geological Survey of Canada) C C. Kevin Boyce (Department of Geological Sciences, Stanford University) A Andrea Corpolongo (Department of Geosciences, University of Cincinnati) A Andrew D. Czaja (Department of Geosciences, University of Cincinnati) S Souvik Das (State Key Laboratory of Critical Earth Material Cycling and Mineral Deposits, Nanjing University) R Robert R. Gaines (Geology Department, Pomona College) D Daniel D. Gregory (Department of Earth Sciences, University of Toronto) J John A. Jaszczak (A. E. Seaman Mineral Museum and Department of Physics, Michigan Technological University) E Emmanuelle J. Javaux (Department of Geology, University of Liège) J Jaganmoy Jodder (Department of Geosciences, University of Oslo) A Andrew H. Knoll (Department of Organismic and Evolutionary Biology, Harvard University) M Martin Van Kranendonk (School of Biological, Earth and Environmental Sciences, University of New South Wales) K Katie M. Maloney (Department of Earth and Environmental Sciences, Michigan State University) N Nora Noffke (Department of Ocean and Earth Sciences, Old Dominion University) R Robert Rainbird (Geological Survey of Canada) E Emersyn Slaughter (Department of Geological Sciences, University of Florida) E Eva E. Stüeken (School of Earth and Environmental Sciences, University of St. Andrews) R Roger E. Summons (Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology) F Frances Westall (Centre de Biophysique Moléculaire, CNRS-UPR4301) J Jasmina Wiemann S Shuhai Xiao (Department of Geosciences, Virginia Tech) R Robert M. Hazen (Earth and Planets Laboratory, Carnegie Institution for Science)

Abstract

Throughout Earth’s history, organic molecules from both abiogenic and biogenic sources have been buried in sedimentary rocks. Most of these organic molecules have been significantly altered by geologic processes through deep time. Nonetheless, the nature and distribution of those ancient fragmentary organic remains have the potential to reveal diagnostic biomolecular information after billions of years of burial. Here, we analyzed 406 fossil, modern biological, meteoritic, and synthetic samples using pyrolysis gas chromatography and mass spectrometry. We explored these analytical data via supervised machine-learning methods to discriminate samples of biogenic vs. abiogenic origin, plant vs. animal phylogenetic affinity, and photosynthetic vs. nonphotosynthetic physiology. Dividing 272 samples with known phylogenetic affinity and physiology into 9 categories, each further divided into 75% training and 25% testing sets, our random forest models accurately predict pairwise assignments of modern vs. fossil or meteoritic organics (100% correct assignments), fossil plant tissues vs. meteoritic organics (97%), modern vs. fossil plant tissues (98%), and modern plants vs. animal tissues (95%). Pairwise comparisons between fossil biogenic samples vs. abiogenic samples resulted in 93% correct classifications, while analysis of modern and ancient photosynthetic vs. nonphotosynthetic samples also resulted in 93% correct assignments. Our analyses demonstrate that molecular biosignatures can survive in ancient fossils and allow for the identification of organismal origins and traits. Consistent with previous morphological and isotopic inferences, we present evidence for biogenic molecular assemblages in Paleoarchean rocks (3.33 Ga) and for photoautotrophy in Neoarchean rocks (2.52 Ga).

Article Details

Volume / Issue Vol. 122, Issue 47
Published November 25, 2025
ISSN 0027-8424
Publisher National Academy of Sciences

Authors (29)

M

Michael L. Wong

A

Anirudh Prabhu

Earth and Planets Laboratory, Carnegie Institution for Science

C

Conel O’D. Alexander

Earth and Planets Laboratory, Carnegie Institution for Science

H

H. James Cleaves

Earth and Planets Laboratory, Carnegie Institution for Science

G

George D. Cody

Earth and Planets Laboratory, Carnegie Institution for Science

G

Grethe Hystad

Department of Mathematics and Statistics, Purdue University Northwest

M

Marko Bermanec

Department of Earth Sciences, University of Graz

W

Wouter Bleeker

Geological Survey of Canada

C

C. Kevin Boyce

Department of Geological Sciences, Stanford University

A

Andrea Corpolongo

Department of Geosciences, University of Cincinnati

A

Andrew D. Czaja

Department of Geosciences, University of Cincinnati

S

Souvik Das

State Key Laboratory of Critical Earth Material Cycling and Mineral Deposits, Nanjing University

R

Robert R. Gaines

Geology Department, Pomona College

D

Daniel D. Gregory

Department of Earth Sciences, University of Toronto

J

John A. Jaszczak

A. E. Seaman Mineral Museum and Department of Physics, Michigan Technological University

E

Emmanuelle J. Javaux

Department of Geology, University of Liège

J

Jaganmoy Jodder

Department of Geosciences, University of Oslo

A

Andrew H. Knoll

Department of Organismic and Evolutionary Biology, Harvard University

M

Martin Van Kranendonk

School of Biological, Earth and Environmental Sciences, University of New South Wales

K

Katie M. Maloney

Department of Earth and Environmental Sciences, Michigan State University

N

Nora Noffke

Department of Ocean and Earth Sciences, Old Dominion University

R

Robert Rainbird

Geological Survey of Canada

E

Emersyn Slaughter

Department of Geological Sciences, University of Florida

E

Eva E. Stüeken

School of Earth and Environmental Sciences, University of St. Andrews

R

Roger E. Summons

Department of Earth, Atmospheric and Planetary Sciences, Massachusetts Institute of Technology

F

Frances Westall

Centre de Biophysique Moléculaire, CNRS-UPR4301

J

Jasmina Wiemann

S

Shuhai Xiao

Department of Geosciences, Virginia Tech

R

Robert M. Hazen

Earth and Planets Laboratory, Carnegie Institution for Science