Oral Nirmatrelvir–Ritonavir for Covid-19 in Higher-Risk Outpatients

C Christopher C. Butler (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) A Andrew D. Pinto (Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto) V Victoria Harris (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) J Jane Holmes (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) N Najib M. Rahman L Lucy Cureton (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) G Gail Hayward (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) D Duncan B. Richards (Department of Medicine, University of Cambridge, Cambridge, United Kingdom) D David M. Lowe (Institute of Immunity and Transplantation, University College London, London) J Joseph F. Standing (Institute of Immunity and Transplantation, University College London, London) J Judith Breuer K Kerenza Hood (Centre for Trials Research, Cardiff University, Cardiff, United Kingdom) M May Ee Png (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) S Stavros Petrou J Jienchi Dorward (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) M Mahendra G. Patel (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) N Nicholas P.B. Thomas (National Institute Health and Care Research Delivery Network, London) P Philip Evans (National Institute Health and Care Research Delivery Network, London) N Nigel D. Hart (School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, United Kingdom) B Bhautesh D. Jani (General Practice and Primary Care, School of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, United Kingdom) B Banafshe Hosseini (Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto) S Srinivas Murthy (Faculty of Medicine, University of British Columbia, Vancouver, Canada) K Kerry McBrien A Amanda Condon (Department of Family Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada) E Emily G. McDonald (Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal) P Peter Daley (Memorial University of Newfoundland, St. John’s, Canada) M Michelle Greiver B Bruno R. da Costa (Dalla Lana School of Public Health, University of Toronto, Toronto) P Peter Selby P Peter Jüni (Dalla Lana School of Public Health, University of Toronto, Toronto) T Todd C. Lee (Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal) H Haolun Shi (Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada) M Michelle A. Detry (Berry Consultants, Austin, TX) C Christina T. Saunders (Berry Consultants, Austin, TX) M Mark Fitzgerald (Berry Consultants, Austin, TX) N Nicholas S. Berry (Berry Consultants, Austin, TX) B Benjamin R. Saville (Berry Consultants, Austin, TX) S Saye H. Khoo (Centre for Experimental Therapeutics, University of Liverpool, Liverpool, United Kingdom) J Jonathan S. Nguyen-Van-Tam (Lifespan and Population Health Unit, University of Nottingham School of Medicine, Nottingham, United Kingdom) F F.D. Richard Hobbs (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) L Ly-Mee Yu (Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom) P Paul Little

Article Details

Volume / Issue Vol. 394, Issue 16
Published April 23, 2026
Pages 1583-1594
ISSN 0028-4793
Publisher Massachusetts Medical Society

Journal Info

New England Journal of Medicine

Massachusetts Medical Society

ISSN: 0028-4793 Social Sciences

Authors (42)

C

Christopher C. Butler

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

A

Andrew D. Pinto

Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto

V

Victoria Harris

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

J

Jane Holmes

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

N

Najib M. Rahman

L

Lucy Cureton

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

G

Gail Hayward

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

D

Duncan B. Richards

Department of Medicine, University of Cambridge, Cambridge, United Kingdom

D

David M. Lowe

Institute of Immunity and Transplantation, University College London, London

J

Joseph F. Standing

Institute of Immunity and Transplantation, University College London, London

J

Judith Breuer

K

Kerenza Hood

Centre for Trials Research, Cardiff University, Cardiff, United Kingdom

M

May Ee Png

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

S

Stavros Petrou

J

Jienchi Dorward

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

M

Mahendra G. Patel

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

N

Nicholas P.B. Thomas

National Institute Health and Care Research Delivery Network, London

P

Philip Evans

National Institute Health and Care Research Delivery Network, London

N

Nigel D. Hart

School of Medicine, Dentistry and Biomedical Sciences, Queen’s University Belfast, United Kingdom

B

Bhautesh D. Jani

General Practice and Primary Care, School of Health and Wellbeing, MVLS, University of Glasgow, Glasgow, United Kingdom

B

Banafshe Hosseini

Upstream Lab, MAP Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, Unity Health Toronto, Toronto

S

Srinivas Murthy

Faculty of Medicine, University of British Columbia, Vancouver, Canada

K

Kerry McBrien

A

Amanda Condon

Department of Family Medicine, Max Rady College of Medicine, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Canada

E

Emily G. McDonald

Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal

P

Peter Daley

Memorial University of Newfoundland, St. John’s, Canada

M

Michelle Greiver

B

Bruno R. da Costa

Dalla Lana School of Public Health, University of Toronto, Toronto

P

Peter Selby

P

Peter Jüni

Dalla Lana School of Public Health, University of Toronto, Toronto

T

Todd C. Lee

Department of Medicine, Faculty of Medicine and Health Sciences, McGill University, Montreal

H

Haolun Shi

Department of Statistics and Actuarial Science, Simon Fraser University, Burnaby, BC, Canada

M

Michelle A. Detry

Berry Consultants, Austin, TX

C

Christina T. Saunders

Berry Consultants, Austin, TX

M

Mark Fitzgerald

Berry Consultants, Austin, TX

N

Nicholas S. Berry

Berry Consultants, Austin, TX

B

Benjamin R. Saville

Berry Consultants, Austin, TX

S

Saye H. Khoo

Centre for Experimental Therapeutics, University of Liverpool, Liverpool, United Kingdom

J

Jonathan S. Nguyen-Van-Tam

Lifespan and Population Health Unit, University of Nottingham School of Medicine, Nottingham, United Kingdom

F

F.D. Richard Hobbs

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

L

Ly-Mee Yu

Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, United Kingdom

P

Paul Little