Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing

Julia E. Rood; Suh Kyung Yoon; Mary K. Heard; Stephen D. Carro; Emma J. Hedgepeth; Mary E. O’Mara; Michael J. Hogan; Nhu Le; Hiromi Muramatsu; Kieu Lam; Petra Schreiner; Coral Kasden; Hansell H. Stedman; Ryan A. Langlois; James Heyes; Norbert Pardi; Laurence C. Eisenlohr

doi:10.1038/s41467-025-68080-x

Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing

J Julia E. Rood S Suh Kyung Yoon M Mary K. Heard S Stephen D. Carro E Emma J. Hedgepeth M Mary E. O’Mara M Michael J. Hogan N Nhu Le H Hiromi Muramatsu (Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania) K Kieu Lam P Petra Schreiner C Coral Kasden H Hansell H. Stedman R Ryan A. Langlois (Department of Microbiology and Immunology, University of Minnesota) J James Heyes N Norbert Pardi L Laurence C. Eisenlohr

Download PDF View Original

APA MLA Chicago BibTeX RIS

Article Details

Journal Nature Communications

Volume / Issue Vol. 17, Issue 1

Published January 16, 2026

DOI 10.1038/s41467-025-68080-x

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (17)

J

Julia E. Rood

S

Suh Kyung Yoon

M

Mary K. Heard

S

Stephen D. Carro

E

Emma J. Hedgepeth

M

Mary E. O’Mara

M

Michael J. Hogan

N

Nhu Le

H

Hiromi Muramatsu

Division of Infectious Diseases, Perelman School of Medicine, University of Pennsylvania

K

Kieu Lam

P

Petra Schreiner

C

Coral Kasden

H

Hansell H. Stedman

R

Ryan A. Langlois

Department of Microbiology and Immunology, University of Minnesota

J

James Heyes

N

Norbert Pardi

L

Laurence C. Eisenlohr

Optimal murine CD4+ T cell priming by mRNA-lipid nanoparticle vaccines requires endogenous antigen processing

Article Details

Journal Info

Authors (17)

Related Articles from this Journal

Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization

Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain