Oligodendrocyte precursor cells facilitate neuronal lysosome release
Abstract
Abstract Oligodendrocyte precursor cells (OPCs) shape brain function through many non-canonical regulatory mechanisms beyond myelination. Here we show that OPCs form contacts with their processes on neuronal somata in a neuronal activity-dependent manner. These contacts facilitate exocytosis of neuronal lysosomes. A reduction in the number or branching of OPCs reduces these contacts, which is associated with lysosome accumulation and altered metabolism in neurons and more senescent neurons with age. A similar reduction in OPC branching and neuronal lysosome accumulation is seen in an early-stage mouse model of Alzheimer’s disease. Our findings have implications for the prevention of age-related pathologies and the treatment of neurodegenerative diseases.
Article Details
Authors (24)
Li-Pao Fang
Ching-Hsin Lin
Yasser Medlej
Renping Zhao
Hsin-Fang Chang
Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, Saarland University
Qilin Guo
Zhonghao Wu
Yixun Su
Na Zhao
Davide Gobbo
Amanda Wyatt
Vanessa Wahl
Max-Planck Institut für Molekulare Pflanzenphysiologie
Frederic Fiore
Szu-Min Tu
Department of Cellular Neurophysiology, Center for Integrative Physiology and Molecular Medicine, Saarland University
Ulrich Boehm
Wenhui Huang
Shan Bian
Amit Agarwal
Marcel A. Lauterbach
Chenju Yi
Research Centre
Jianqin Niu
Anja Scheller
Frank Kirchhoff
Institute of Molecular Virology, Ulm University Medical Center
Xianshu Bai