O-linked glycan-dependent gating of TPC2 controls lysosomal excitability and organelle remodeling

A Alice Lin (Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University) N Neng-Yu Lin M Marco Keller (Pharmaceutical Chemistry, Department of Pharmacy, Center for Drug Research) R Ramona Schütz Y Yi-Zhen Wu W William Burton N Novelyn Putri Kinanti C Chi-Yuan Yao N Nicole Urban Y Ya-Wen Liu F Franz Bracher (Pharmaceutical Chemistry, Department of Pharmacy, Center for Drug Research) A Antony Galione (Department of Pharmacology, University of Oxford) H Hao-Jen Hsu C Ching-Ying Kuo C Cheng-Chang Chen (Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University)

Article Details

Volume / Issue Vol. 17, Issue 1
Published June 10, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (15)

A

Alice Lin

Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University

N

Neng-Yu Lin

M

Marco Keller

Pharmaceutical Chemistry, Department of Pharmacy, Center for Drug Research

R

Ramona Schütz

Y

Yi-Zhen Wu

W

William Burton

N

Novelyn Putri Kinanti

C

Chi-Yuan Yao

N

Nicole Urban

Y

Ya-Wen Liu

F

Franz Bracher

Pharmaceutical Chemistry, Department of Pharmacy, Center for Drug Research

A

Antony Galione

Department of Pharmacology, University of Oxford

H

Hao-Jen Hsu

C

Ching-Ying Kuo

C

Cheng-Chang Chen

Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University