Novel Human Heart–Derived Natural Adeno-Associated Virus Capsid Combines Cardiospecificity With Cardiotropism In Vivo

D Daniel Zeissler (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) M Martin Busch S Sebastian Grieskamp (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) E Eric Meinhardt (Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) H Hanna Wurzer (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) S Shubhada R. Kulkarni (Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) A Anna K. Schrattel (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) S Stephanie Molter (Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) D Dorothea Kehr (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) M Maria Qatato (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) C Christoph Rummel A Arne Hansen (Institute of Experimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (A.H., M.L., K.M.W.).) M Malte Loos (Institute of Experimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (A.H., M.L., K.M.W.).) K Kinga M. Wrona (Institute of Experimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (A.H., M.L., K.M.W.).) M Mirko Völkers V Vivien Kmietczyk (Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) J Julia Wingert (Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) V Viet Loan Dao Thi J Jungen Hu P Philipp Schlegel C Christoph Dieterich H Hugo A. Katus (Deutsches Zentrum für Herz- und Kreislaufforschung, Partner Site Heidelberg/Mannheim, Heidelberg, Germany (M.B., E.M., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., H.A.K., N.F., J.R., P.M.).) N Norbert Frey A Andreas Jungmann (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) J Julia Ritterhoff (Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.) P Patrick Most

Article Details

Journal Circulation
Volume / Issue Vol. 152, Issue 6
Published August 12, 2025
Pages 416-419
ISSN 0009-7322
Publisher Lippincott Williams & Wilkins

Journal Info

Circulation

Lippincott Williams & Wilkins

ISSN: 0009-7322 Health Sciences

Authors (26)

D

Daniel Zeissler

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

M

Martin Busch

S

Sebastian Grieskamp

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

E

Eric Meinhardt

Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

H

Hanna Wurzer

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

S

Shubhada R. Kulkarni

Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

A

Anna K. Schrattel

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

S

Stephanie Molter

Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

D

Dorothea Kehr

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

M

Maria Qatato

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

C

Christoph Rummel

A

Arne Hansen

Institute of Experimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (A.H., M.L., K.M.W.).

M

Malte Loos

Institute of Experimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (A.H., M.L., K.M.W.).

K

Kinga M. Wrona

Institute of Experimental Pharmacology and Toxicology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (A.H., M.L., K.M.W.).

M

Mirko Völkers

V

Vivien Kmietczyk

Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

J

Julia Wingert

Department of Internal Medicine III (D.Z., M.B., S.G., E.M., H.W., S.R.K., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., N.F., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

V

Viet Loan Dao Thi

J

Jungen Hu

P

Philipp Schlegel

C

Christoph Dieterich

H

Hugo A. Katus

Deutsches Zentrum für Herz- und Kreislaufforschung, Partner Site Heidelberg/Mannheim, Heidelberg, Germany (M.B., E.M., A.K.S., S.M., D.K., M.Q., M.V., V.K., J.W., P.S., C.D., H.A.K., N.F., J.R., P.M.).

N

Norbert Frey

A

Andreas Jungmann

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

J

Julia Ritterhoff

Division of Molecular and Translational Cardiology (D.Z., M.B., S.G., H.W., A.K.S., D.K., M.Q., A.J., J.R., P.M.), University Hospital Heidelberg, Germany.

P

Patrick Most