NMR-Based Rational Drug Design of G:G Mismatch DNA Binding Ligand Trapping Transient Complex via Disruption of a Key Allosteric Interaction

Shuhei Sakurabayashi

Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (SANKEN), Osaka University, 8-1 Mihogaoka, Osaka, Ibaraki 567-0047, Japan

Kyoko Furuita

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, Suita 565-0871, Japan

Takeshi Yamada

Neutron Science and Technology Center, Comprehensive Research Organization for Science and Society, Tokai, Naka, Ibaraki 319-1106, Japan

Noriaki Sugiura

Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (SANKEN), Osaka University, 8-1 Mihogaoka, Osaka, Ibaraki 567-0047, Japan

Makoto Nomura

Graduate School of Biological Sciences, Nara Institute of Science and Technology, 8916-5 Takayama, Ikoma, Nara 630-0192, Japan

Takanori Nakane

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, Suita 565-0871, Japan

Akihiro Kawamoto

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, Suita 565-0871, Japan

Genji Kurisu

Yohei Miyanoiri

Exploratory Research Center on Life and Living Systems (ExCELLS), National Institutes of Natural Sciences, 5-1 Myodaiji, Okazaki, Aichi 444-8787, Japan

Toshimichi Fujiwara

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, Suita 565-0871, Japan

Kazuhiko Nakatani

Department of Regulatory Bioorganic Chemistry, The Institute of Scientific and Industrial Research (SANKEN), Osaka University, 8-1 Mihogaoka, Osaka, Ibaraki 567-0047, Japan

Chojiro Kojima

Institute for Protein Research, Osaka University, 3-2 Yamadaoka, Osaka, Suita 565-0871, Japan