Nickel‐Catalyzed Asymmetric Hydrophosphinamidation of Alkynes
Abstract
ABSTRACT P ‐stereogenic phosphinamidates are highly pivotal structural motifs in drug discovery and the design of chiral ligands. Despite their utility, catalytic enantioselective access to these compounds remains a formidable challenge. Herein, we report the first nickel‐catalyzed asymmetric hydrophosphinamidation of alkynes. This protocol enables the highly efficient and enantioselective synthesis of structurally diverse alkenyl phosphinamidates, accommodating a wide array of both N, N ‐dialkyl and N ‐alkyl substituted H ‐phosphinamides. Notably, the resulting products exhibit orthogonal reactivities at four distinct sites, serving as a powerful and universal platform for the divergent synthesis of complex P ‐stereogenic architectures.
Article Details
Authors (8)
Li Gao
Jia‐Zhong Tang
Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry University of Science and Technology of China Hefei China
Meng‐Xiang Li
Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry University of Science and Technology of China Hefei China
Jun‐Ze Rong
Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry University of Science and Technology of China Hefei China
Hoonam Tahvildari
Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry University of Science and Technology of China Hefei China
Chang‐Jiang Yang
Department of Chemistry, School of Sciences and Guangdong Provincial Key Laboratory of Mathematical and Neural Dynamical Systems Great Bay University Dongguan China
Lin Liu
Qing‐Wei Zhang
Key Laboratory of Precision and Intelligent Chemistry, Department of Chemistry University of Science and Technology of China Hefei China