Neuroimaging insights into recent suicide attempters utilizing the raven task

Abstract

Background Understanding brain function in individuals who have recently attempted suicide is critical for improving diagnosis and treatment strategies. This study aimed to examine neural activity patterns in such individuals (who had attempted suicide 1–4 weeks before the study) using functional magnetic resonance imaging (fMRI) and the General Linear Model (GLM). Methods Sixty participants were recruited and categorized into three groups: individuals with a recent suicide attempt and Major Depressive Disorder (SA + MDD), individuals with Major Depressive Disorder without a suicide attempt (MDD), and healthy controls (HC). Participants performed the Raven task, consisting of 24 trials with a 25-second time limit for each item. Brain activity was analyzed to identify regional differences among groups using ANOVA, followed by Tukey’s post-hoc pairwise comparisons. Results Compared to the MDD and HC groups, the SA + MDD group exhibited significantly reduced activation in the left medial superior frontal cortex (SFC), left anterior cingulate cortex (ACC), and left precentral gyrus. Positive correlations were observed between the Scale for Suicidal Ideation scores and activity in the medial SFC and ACC, whereas a negative correlation was found with precentral gyrus activity. While task accuracy did not significantly differ among the groups, the SA + MDD group demonstrated significantly shorter response durations. Conclusion Individuals with recent suicide attempts show diminished activation in key left-hemispheric regions involved in cognitive control and problem-solving, including the medial SFC, ACC, and precentral gyrus. These neural deficits may impair decision-making and problem-solving abilities, particularly when compounded by hopelessness and a diminished sense of purpose, potentially contributing to increased suicide risk.