Nanoconfinement of Ammonia Borane via Hybrid‐Phased Titanate Nanocrystals Enables Sustained H<sub>2</sub> Release for Diabetic Bone Repair
Abstract
AbstractDespite its potential in hydrogen (H2) therapy, ammonia borane (AB) has limited biomedical applications due to its uncontrolled hydrolysis rate and potential to cause cytotoxicity. Existing material‐based delivery strategies focus on accelerating AB hydrolysis for H2 production, hence exacerbating these issues. A new nanoconfinement strategy is reported, which loads AB onto oxygen‐deficient, hybrid‐phased titanate nanocrystals on implant surfaces through a unique one‐end‐anchored docking (OEAD) mechanism. This nanoconfinement strategy effectively restricts the release of AB molecules, allowing only water molecules to infiltrate the interlayer space for slow hydrolysis and sustained H2 release. This significantly prolongs the duration of H2 release and effectively circumvents the cytotoxicity associated with AB interacting with hydrogen peroxide (H2O2) in the inflammatory microenvironment. In vitro and in vivo have shown that sustained H2 release from the implant surface effectively alleviates diabetes‐related oxidative stress, and combined with the release of magnesium ions (Mg2+) synergistically promotes innervated‐vascularized bone regeneration.
Article Details
Authors (18)
Yuan Zhang
Fuwei Liu
Nanophotonics and Biophotonics Key Laboratory of Jilin Province, School of Physics, Changchun University of Science and Technology , Changchun 130022,
Minggang Yang
Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China
He Xin
Ben Wu
Jiao Jiao Li
School of Biomedical Engineering Faculty of Engineering and IT University of Technology Sydney Sydney NSW 2007 Australia
Haibo Tao
Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China
Yichen Chen
Junkang Chen
Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China
Qingqing Guan
Key Laboratory of Oil and Gas Fine Chemicals of Ministry of Education, College of Chemical Engineering
Zundong Liu
Zhengjiang Xu
Research Center for Human Tissues and Organs Degeneration Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen 518055 P. R. China
Jia Pei
Shanghai Key Laboratory of Hydrogen Science & Center of Hydrogen Science School of Materials Science and Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China
Sergio Moya
Soft Matter Nanotechnology Center for Cooperative Research in Biomaterials (CIC biomaGUNE) Basque Research and Technology Alliance (BRTA) Paseo de Miramon 194 Donostia‐San Sebastián 20014 Spain
Haobo Pan
Xiaobing Zhao
Liang Kong
Guocheng Wang
Center for Systems and Control