Multistate Structure Determination and Dynamics Analysis Reveals a Unique Ubiquitin-Recognition Mechanism in Ubiquitin C-terminal Hydrolase

M Mayu Okada (Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan) Y Yutaka Tateishi (Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan) E Eri Nojiri (International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan) T Tsutomu Mikawa (Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan) S Sundaresan Rajesh (International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan) H Hiroki Ogasa (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) T Takumi Ueda (Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan) H Hiromasa Yagi (RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama230-0045, Japan) T Toshiyuki Kohno (Department of Medical Informatics, Research and Development Center for Medical Education, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan) T Takanori Kigawa (RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama230-0045, Japan) I Ichio Shimada (RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan) P Peter Güntert (Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan) Y Yutaka Ito (Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan) T Teppei Ikeya (Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan)

Article Details

Volume / Issue Vol. 147, Issue 33
Published August 20, 2025
Pages 29884-29894
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (14)

M

Mayu Okada

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan

Y

Yutaka Tateishi

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan

E

Eri Nojiri

International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

T

Tsutomu Mikawa

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan

S

Sundaresan Rajesh

International Graduate School of Arts and Sciences, Yokohama City University, 1-7-29 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan

H

Hiroki Ogasa

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

T

Takumi Ueda

Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

H

Hiromasa Yagi

RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama230-0045, Japan

T

Toshiyuki Kohno

Department of Medical Informatics, Research and Development Center for Medical Education, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami-ku, Sagamihara, Kanagawa 252-0374, Japan

T

Takanori Kigawa

RIKEN Center for Biosystems Dynamics Research, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama230-0045, Japan

I

Ichio Shimada

RIKEN Center for Integrative Medical Sciences (IMS), 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0045, Japan

P

Peter Güntert

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan

Y

Yutaka Ito

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan

T

Teppei Ikeya

Department of Chemistry, Graduate School of Science, Tokyo Metropolitan University, 1-1 minamiosawa, Hachioji, Tokyo 192-0397, Japan