Multicyclic Peptides Targeting PD-L1 for Radiotheranostics: From Discovery to Clinical Proof-of-Concept

X Xueting Cheng (Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) S Shuo Jiang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) X Xingtong Peng (Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital) P Pan Yang (University of Miami , , , ,) S Siqi Zhang (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) C Chaoying Xu (Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) X Xin Gao S Shihui Fan (Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) H Hongtan Liu (Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) J Jie Zhuang (Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) X Xueyao Chen (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) N Naixin Liang (Department of Thoracic Surgery, Peking Union Medical College Hospital) B Bingni Lin (Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces) Q Qingshuang Lu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica) M Meirong Chen (School of Pharmacy, State Key Laboratory of Natural Medicines) Y Yibei Xiao (School of Pharmacy, State Key Laboratory of Natural Medicines) Z Zhaohui Zhu (Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital) R Rui Wang K Kuan Hu C Chuanliu Wu (Department of Chemistry, College of Chemistry and Chemical Engineering, the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces)

Article Details

Volume / Issue Vol. 147, Issue 39
Published October 01, 2025
Pages 35638-35654
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (20)

X

Xueting Cheng

Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

S

Shuo Jiang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

X

Xingtong Peng

Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital

P

Pan Yang

University of Miami , , , ,

S

Siqi Zhang

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

C

Chaoying Xu

Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

X

Xin Gao

S

Shihui Fan

Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

H

Hongtan Liu

Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

J

Jie Zhuang

Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

X

Xueyao Chen

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

N

Naixin Liang

Department of Thoracic Surgery, Peking Union Medical College Hospital

B

Bingni Lin

Department of Chemistry, College of Chemistry and Chemical Engineering, The MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces

Q

Qingshuang Lu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica

M

Meirong Chen

School of Pharmacy, State Key Laboratory of Natural Medicines

Y

Yibei Xiao

School of Pharmacy, State Key Laboratory of Natural Medicines

Z

Zhaohui Zhu

Department of Nuclear Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Peking Union Medical College Hospital

R

Rui Wang

K

Kuan Hu

C

Chuanliu Wu

Department of Chemistry, College of Chemistry and Chemical Engineering, the MOE Key Laboratory of Spectrochemical Analysis and Instrumentation, State Key Laboratory of Physical Chemistry of Solid Surfaces