Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors

Xuefeng Wang; Tingyi Li; Islam Eljilany; Alex Soupir; Michael Radmacher; Phaedra Agius; Vineeth Sukrithan; Aakrosh Ratan; Martin McCarter; Bodour Salhia; Howard Colman; Abdul R. Naqash; Igor Puzanov; Susanne Arnold; Julian A. Marin-Acevedo; Shridar Ganesan; Michelle Churchman; Patrick Hwu; Paulo C. Rodriguez; William S. Dalton; George J. Weiner; Ahmad A. Tarhini

doi:10.1038/s41467-025-65016-3

Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors

X Xuefeng Wang (Beijing National Laboratory for Condensed Matter Physics) T Tingyi Li I Islam Eljilany A Alex Soupir M Michael Radmacher P Phaedra Agius V Vineeth Sukrithan A Aakrosh Ratan (University of Virginia, Charlottesville, VA, USA.) M Martin McCarter B Bodour Salhia H Howard Colman A Abdul R. Naqash I Igor Puzanov S Susanne Arnold J Julian A. Marin-Acevedo S Shridar Ganesan M Michelle Churchman P Patrick Hwu P Paulo C. Rodriguez W William S. Dalton G George J. Weiner A Ahmad A. Tarhini

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published November 13, 2025

DOI 10.1038/s41467-025-65016-3

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (22)

X

Xuefeng Wang

Beijing National Laboratory for Condensed Matter Physics

T

Tingyi Li

I

Islam Eljilany

A

Alex Soupir

M

Michael Radmacher

P

Phaedra Agius

V

Vineeth Sukrithan

A

Aakrosh Ratan

University of Virginia, Charlottesville, VA, USA.

M

Martin McCarter

B

Bodour Salhia

H

Howard Colman

A

Abdul R. Naqash

I

Igor Puzanov

S

Susanne Arnold

J

Julian A. Marin-Acevedo

S

Shridar Ganesan

M

Michelle Churchman

P

Patrick Hwu

P

Paulo C. Rodriguez

W

William S. Dalton

G

George J. Weiner

A

Ahmad A. Tarhini

Multicellular immune ecotypes within solid tumors predict real-world therapeutic benefits with immune checkpoint inhibitors

Article Details

Journal Info

Authors (22)

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