mRNA-Based FRET-FLIM Imaging Platform for Quantifying Lipid Nanoparticle Endosomal Escape and Membrane Damage

Y Yian Fang (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) B Bin Ma (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) Z Zhiqiang Zhao (Department of Materials Science and Engineering) Z Ziyan Xuan (Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering) Y Yu Wang C Chuping Huang (Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering) M Mi Zhang (Guangdong Provincial Key Laboratory of Carbon Dioxide Resource Utilization, School of Chemistry) L Lei Zhou F Feng Yao (Shanghai Hongene Biotech Corporation) K Kailong Li (Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences) W Wei You (Department of Polymer Science and Engineering) X Xinglin Yang (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) J Jiajia Guo (Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences) Y Yifan Ge C Chenzhong Liao Y Yiguang Wang (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences) L Lei Miao (State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences)

Article Details

Volume / Issue Vol. 147, Issue 34
Published August 27, 2025
Pages 30907-30923
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (17)

Y

Yian Fang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

B

Bin Ma

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

Z

Zhiqiang Zhao

Department of Materials Science and Engineering

Z

Ziyan Xuan

Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering

Y

Yu Wang

C

Chuping Huang

Department of Pharmaceutical Sciences and Engineering, School of Food and Biological Engineering

M

Mi Zhang

Guangdong Provincial Key Laboratory of Carbon Dioxide Resource Utilization, School of Chemistry

L

Lei Zhou

F

Feng Yao

Shanghai Hongene Biotech Corporation

K

Kailong Li

Department of Biochemistry and Molecular Biology, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, School of Basic Medical Sciences

W

Wei You

Department of Polymer Science and Engineering

X

Xinglin Yang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

J

Jiajia Guo

Institute of Biomedical and Health Engineering, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences

Y

Yifan Ge

C

Chenzhong Liao

Y

Yiguang Wang

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences

L

Lei Miao

State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences