Motion impact score for detecting spurious brain-behavior associations
Abstract
Abstract In-scanner head motion introduces systematic bias to resting-state fMRI functional connectivity (FC) not completely removed by denoising algorithms. Researchers studying traits associated with motion (e.g. psychiatric disorders) need to know if their trait-FC relationships are impacted by residual motion to avoid reporting false positive results. We devised Split Half Analysis of Motion Associated Networks (SHAMAN) to assign a motion impact score to specific trait-FC relationships. SHAMAN distinguishes between motion causing overestimation or underestimation of trait-FC effects. We assessed 45 traits from n = 7270 participants in the Adolescent Brain Cognitive Development (ABCD) Study. After standard denoising with ABCD-BIDS and without motion censoring, 42% (19/45) of traits had significant (p < 0.05) motion overestimation scores and 38% (17/45) had significant underestimation scores. Censoring at framewise displacement (FD) < 0.2 mm reduced significant overestimation to 2% (1/45) of traits but did not decrease the number of traits with significant motion underestimation scores.
Article Details
Authors (38)
Benjamin P. Kay
David F. Montez
Scott Marek
Brenden Tervo-Clemmens
Institute of Child Development, University of Minnesota
Joshua S. Siegel
Department of Psychiatry, New York University, Langone Center for Psychedelic Medicine, New York University Grossman School of Medicine
Babatunde Adeyemo
Timothy O. Laumann
Athanasia Metoki
Roselyne J. Chauvin
Department of Neurology, Washington University School of Medicine
Andrew N. Van
Vahdeta Suljic
Samuel R. Krimmel
Department of Neurology, Washington University School of Medicine
Ryland L. Miller
Dillan J. Newbold
Department of Neurology, New York University Medical Center
Annie Zheng
Nicole A. Seider
Kristen M. Scheidter
Julia S. Monk
Eric Feczko
Masonic Institute for the Developing Brain, University of Minnesota
Anita Randolph
Óscar Miranda-Domínguez
Lucille A. Moore
Masonic Institute for the Developing Brain, University of Minnesota
Anders J. Perrone
Gregory M. Conan
Eric A. Earl
Stephen M. Malone
Department of Psychology, University of Minnesota
Michaela Cordova
Olivia Doyle
Benjamin J. Lynch
James C. Wilgenbusch
Thomas Pengo
Alice M. Graham
Jarod L. Roland
Evan M. Gordon
Abraham Z. Snyder
Department of Radiology, Washington University School of Medicine
Deanna M. Barch
Department of Psychiatry, Washington University in St. Louis
Damien A. Fair
Department of Pediatrics, University of Minnesota
Nico U. F. Dosenbach