Monodentate Formate‐Mediated Toluene Methylation to Xylene at Low Temperature Using Formic Acid and Hydrogen

J Jiachang Zuo (State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China) C Chong Liu (Department of Chemistry and Biochemistry) B Bilyu Hong (State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China) Q Qiongjin Jiang (State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China) Z Zhenyu Yang J Jia Liu W Wen Zhou Y Yingjie Lai (State Key Laboratory of Catalysis, National Laboratory for Clean Energy, 2011-Collaborative Innovation Center of Chemistry for Energy Materials) T Tom Backhouse (Johnson Matthey Public Limited Company London EC4A 4AB UK) L Linmin Ye (State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China) Y Yongjin Luo (Fujian Key Laboratory of Pollution Control and Resource Reuse College of Environmental and Resource Sciences Fujian Normal University Fuzhou 350007 China) W Wei Zhuang H Han Xu Y Youzhu Yuan (State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering)

Abstract

Abstract The industrial methanol–toluene methylation process for xylene production faces a challenge of lowering the reaction temperature while suppressing the side reaction of methanol to hydrocarbons. This depends on the low‐temperature formation of the methoxy intermediate required for methylation. Here, we establish a route for methoxy formation in which formic acid (FA) hydrogenates via a metastable monodentate formate intermediate. With the GaZrO x –ZSM‐5 catalyst, Ga–H bonds act as a “placeholder”, enabling FA adsorption as a monodentate formate rather than a stable bridged formate. At 300 °C and 3.0 MPa, toluene conversion reaches 13.9% with 77.6% xylene selectivity, outperforming established routes. Kinetic isotope effect experiments revealed that Ga‐based catalysts show a secondary isotope effect, whereas non‐Ga catalysts exhibit an inverse isotope effect. Density functional theory calculations indicated that the monodentate formate was more susceptible to hydrogenation which then facilitated methylation. This work provides a competitive route for xylene production from toluene under mild conditions using sustainable FA and H 2 .

Article Details

Volume / Issue Vol. 65, Issue 8
Published February 16, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (14)

J

Jiachang Zuo

State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

C

Chong Liu

Department of Chemistry and Biochemistry

B

Bilyu Hong

State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Q

Qiongjin Jiang

State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Z

Zhenyu Yang

J

Jia Liu

W

Wen Zhou

Y

Yingjie Lai

State Key Laboratory of Catalysis, National Laboratory for Clean Energy, 2011-Collaborative Innovation Center of Chemistry for Energy Materials

T

Tom Backhouse

Johnson Matthey Public Limited Company London EC4A 4AB UK

L

Linmin Ye

State Key Laboratory of Physical Chemistry of Solid Surfaces National Engineering Laboratory for Green Chemical Productions of Alcohols‐Ethers‐Esters College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Y

Yongjin Luo

Fujian Key Laboratory of Pollution Control and Resource Reuse College of Environmental and Resource Sciences Fujian Normal University Fuzhou 350007 China

W

Wei Zhuang

H

Han Xu

Y

Youzhu Yuan

State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering