Modulation of the 14-3-3σ/C-RAF “Auto”inhibited Complex by Molecular Glues

M Markella Konstantinidou (Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)) H Holly R. Vickery (Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)) M Marloes A. M. Pennings (Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)) J Johanna M. Virta (Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)) S Shu Yue Luo (Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)) E Emira J. Visser (Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)) S Sean D. Bannier (Ambagon Therapeutics, de Lismortel 31, Eindhoven 5612AR, The Netherlands) M Mrudula Srikanth (Ambagon Therapeutics, de Lismortel 31, Eindhoven 5612AR, The Netherlands) S Sabine Z. Cismoski (Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)) L Lucy C. Young (Helen Diller Family Comprehensive Cancer Center) M Maxime C. M. van den Oetelaar (Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)) F Frank McCormick C Christian Ottmann (Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)) L Luc Brunsveld (Department of Biomedical Engineering and the Institute for Complex Molecular Systems) M Michelle R. Arkin (Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC))

Article Details

Volume / Issue Vol. 148, Issue 5
Published February 11, 2026
Pages 4951-4965
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (15)

M

Markella Konstantinidou

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)

H

Holly R. Vickery

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)

M

Marloes A. M. Pennings

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)

J

Johanna M. Virta

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)

S

Shu Yue Luo

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)

E

Emira J. Visser

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)

S

Sean D. Bannier

Ambagon Therapeutics, de Lismortel 31, Eindhoven 5612AR, The Netherlands

M

Mrudula Srikanth

Ambagon Therapeutics, de Lismortel 31, Eindhoven 5612AR, The Netherlands

S

Sabine Z. Cismoski

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)

L

Lucy C. Young

Helen Diller Family Comprehensive Cancer Center

M

Maxime C. M. van den Oetelaar

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)

F

Frank McCormick

C

Christian Ottmann

Laboratory of Chemical Biology, Department of Biomedical Engineering and Institute for Complex Molecular Systems (ICMS)

L

Luc Brunsveld

Department of Biomedical Engineering and the Institute for Complex Molecular Systems

M

Michelle R. Arkin

Department of Pharmaceutical Chemistry and Small Molecule Discovery Center (SMDC)