Modulation of oxidative stress and P53/PCNA signaling by glucosodiene-loaded nanoferrites (GLONF) in ehrlich solid tumor–induced hepatotoxicity

Abstract

Abstract Ehrlich solid tumors are commonly used as a model to study tumor growth and evaluate potential anticancer therapies. Current study aimed to assess the curative efficacy of glucosodiene Loaded over Nanoferrites (GLONF) against Ehrlich solid tumor (EST) induced hepatotoxicity. Fifty female mice were randomly allocated into five equal groups (Control; GLONF; EST; GLONF + EST; EST+GLONF). Our findings revealed that the EST group exhibited significantly increased levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), hepatic injury indices, malondialdehyde (MDA), proliferating cell nuclear antigen ( PCNA), and apoptotic p53, while showing significant depletion of albumin, total proteins, catalase, superoxide dismutase (SOD) and reduced glutathione (GSH) when compared to the control group. GLONF post-treatment (EST+ GLONF) is a highly effective strategy, demonstrating potent antitumor where it reduced tumor size, hepatoprotective, and antioxidant actions, restoring liver integrity, modulating key molecular markers and improving histological and immunohistochemical profiles.