Journal of the American Chemical Society

Modulating the Binding Kinetics of Bruton’s Tyrosine Kinase Inhibitors through Transition-State Effects

E Eduardo Bravo (Center for the Advanced Study of Drug Action, Department of Chemistry) Y Yong Li D David Yin-wei Lin (Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology) B Bharath Srinivasan (Center for the Advanced Study of Drug Action, Department of Chemistry) M Marco Barone S Stan Xiaogang Li (Center for the Advanced Study of Drug Action, Department of Chemistry) F Francesca DelloRusso (Center for the Advanced Study of Drug Action, Department of Chemistry) A Anza Suneer Rahiyanath (Center for the Advanced Study of Drug Action, Department of Chemistry) A Ana Corrionero (Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain) P Patricia Alfonso (Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain) N Niall Prendiville (Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain) D Dima Kozakov (Laufer Center for Physical and Quantitative Biology) A Amy H. Andreotti (Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology) P Peter J. Tonge (Center for the Advanced Study of Drug Action, Department of Chemistry)
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Article Details

Volume / Issue Vol. 147, Issue 31
Published August 06, 2025
Pages 27876-27891
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (14)

E

Eduardo Bravo

Center for the Advanced Study of Drug Action, Department of Chemistry

Y

Yong Li

D

David Yin-wei Lin

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology

B

Bharath Srinivasan

Center for the Advanced Study of Drug Action, Department of Chemistry

M

Marco Barone

S

Stan Xiaogang Li

Center for the Advanced Study of Drug Action, Department of Chemistry

F

Francesca DelloRusso

Center for the Advanced Study of Drug Action, Department of Chemistry

A

Anza Suneer Rahiyanath

Center for the Advanced Study of Drug Action, Department of Chemistry

A

Ana Corrionero

Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain

P

Patricia Alfonso

Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain

N

Niall Prendiville

Enzymlogic S.L., QUBE Technology Park, C/Santiago Grisolía, 2, 28760 Madrid, Spain

D

Dima Kozakov

Laufer Center for Physical and Quantitative Biology

A

Amy H. Andreotti

Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology

P

Peter J. Tonge

Center for the Advanced Study of Drug Action, Department of Chemistry

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