Modular Access to Nitriles From Carbonyls via Deoxygenative Transformation With Polarity Inversion
Abstract
ABSTRACT The C─O bond cleavage has always been a central challenge for deoxygenation due to high bond dissociation energies. Here, we develop a Lewis acid‐promoted polarity inversion strategy that enables a strong C─O bond cleavage and rapid access to nitriles from carbonyls. Its broad applicability, together with the nontoxic and mild conditions, underscores the highly modular nature of this method.
Article Details
Authors (6)
Fancong Meng
Shanghai Key Laboratory of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University Shanghai P.R. China
Wenhao Xu
Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. China
Zhigang Wang
Yuanqiang Chen
Shanghai Key Laboratory of Chemical Assessment and Sustainability, School of Chemical Science and Engineering, Tongji University, 1239 Siping Road, Shanghai 200092, P. R. China
Shuntao Xia
Shanghai Key Laboratory of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University Shanghai P.R. China
Tao Xu