Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses

Angelo Y. Meliton; Kun Woo D. Shin; Rengül Cetin-Atalay; M. Volkan Atalay; Yufeng Tian; Jennifer C. Houpy Szafran; Takugo Cho; Kaitlyn A. Sun; Parker S. Woods; Obada R. Shamaa; Bohao Chen; Nickolai O. Dulin; Aliya N. Husain; Alexander Muir; Hardik Shah; Gökhan M. Mutlu; Robert B. Hamanaka

doi:10.1038/s41467-025-64320-2

Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses

A Angelo Y. Meliton K Kun Woo D. Shin R Rengül Cetin-Atalay M M. Volkan Atalay Y Yufeng Tian J Jennifer C. Houpy Szafran T Takugo Cho K Kaitlyn A. Sun P Parker S. Woods O Obada R. Shamaa B Bohao Chen N Nickolai O. Dulin A Aliya N. Husain A Alexander Muir H Hardik Shah G Gökhan M. Mutlu (Department of Medicine, The University of Chicago, Chicago, IL, USA.) R Robert B. Hamanaka (Department of Medicine, The University of Chicago, Chicago, IL, USA.)

Download PDF View Original

APA MLA Chicago BibTeX RIS

Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published October 20, 2025

DOI 10.1038/s41467-025-64320-2

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (17)

A

Angelo Y. Meliton

K

Kun Woo D. Shin

R

Rengül Cetin-Atalay

M

M. Volkan Atalay

Y

Yufeng Tian

J

Jennifer C. Houpy Szafran

T

Takugo Cho

K

Kaitlyn A. Sun

P

Parker S. Woods

O

Obada R. Shamaa

B

Bohao Chen

N

Nickolai O. Dulin

A

Aliya N. Husain

A

Alexander Muir

H

Hardik Shah

G

Gökhan M. Mutlu

Department of Medicine, The University of Chicago, Chicago, IL, USA.

R

Robert B. Hamanaka

Department of Medicine, The University of Chicago, Chicago, IL, USA.

Mitochondrial one-carbon metabolism is required for TGF-β-induced glycine synthesis and fibrotic responses

Article Details

Journal Info

Authors (17)

Related Articles from this Journal

Synthesis of adaptive 15N-nitrosyl-Co7 nanocluster for electrocatalytic C–H functionalization

Pan-Ebolavirus nanoparticle vaccine provides protection in rodents from lethal infection by Zaire and Sudan viruses

Multi-population GWAS meta-analysis identifies bladder cancer susceptibility loci and highlights genetic regulation of smoking-related risk

Genome-wide annotation of human multi-nucleotide variants reveals widespread functional differences from single nucleotide variants

Allele-specific chromatin architecture shapes imprinted domains and coordinates a distal enhancer and antisense transcription at the mouse Mest-Copg2 domain