Mismatched Nucleotide Rejections at the Open and Ajar States of DNA Polymerase I Ensure High Fidelity

Ye Yuan; Hao Wang; Hang Fu; Chenguang Yang; Zhao Lin; Chunhua Xu; Shuxin Hu; Tongsheng Chen; Qi Jia; Ming Li; Ying Lu

doi:10.1021/jacs.5c14087

Journal of the American Chemical Society

Mismatched Nucleotide Rejections at the Open and Ajar States of DNA Polymerase I Ensure High Fidelity

Y Ye Yuan H Hao Wang (Division of Quantitative Sciences, Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland USA) H Hang Fu (Beijing National Laboratory for Condensed Matter Physics, Institute of Physics) C Chenguang Yang (Beijing National Laboratory for Condensed Matter Physics, Institute of Physics) Z Zhao Lin (Beijing National Laboratory for Condensed Matter Physics, Institute of Physics) C Chunhua Xu (Beijing National Laboratory for Condensed Matter Physics, Institute of Physics) S Shuxin Hu (Beijing National Laboratory for Condensed Matter Physics, Institute of Physics) T Tongsheng Chen (MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, School of Optoelectronic Science and Engineering) Q Qi Jia M Ming Li Y Ying Lu

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Article Details

Journal Journal of the American Chemical Society

Volume / Issue Vol. 147, Issue 50

Published December 17, 2025

Pages 46094-46100

DOI 10.1021/jacs.5c14087

ISSN 0002-7863

Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (11)

Y

Ye Yuan

H

Hao Wang

Division of Quantitative Sciences, Department of Oncology Johns Hopkins University School of Medicine Baltimore Maryland USA

H

Hang Fu