Micrometer-sized integrated plasmonic–electroacoustic hybrid transducer for biosensing applications
Abstract
This paper presents the development of an on-chip, micrometer-sized, dual-mode transducing device for biosensing applications. The device integrates two distinct transducing mechanisms: plasmonic transduction based on Au nanoparticles and electro-acoustic transduction based on a film bulk acoustic resonator (FBAR). The device has been fabricated by synthesizing Au nanoislands via thermal dewetting on the top electrode of an AlN-based solidly mounted resonator–FBAR on a Si substrate. The fabrication of the hybrid device employs microelectro-mechanical systems (MEMS)-compatible processes that have been optimized to ensure both structural integrity and optimal electrical and optical responses. The device's ability to detect protein films through electro-acoustic and plasmonic transduction mechanisms is demonstrated by measuring spectral shifts of the electro-acoustic and optical resonances of the device. These shifts are comparable to those of high-performance independent (non-hybrid) optical and electro-acoustic sensors, while offering the benefits of a combined transducing approach, such as the ability to simultaneously measure several independent physical parameters and to provide cross-validation and a reference point. Its compact size and compatibility with MEMS technology make the presented device highly suitable for mass-produced sensor arrays on chips for multiplexed detection in advanced biosensing monitoring.
Article Details
Journal Info
Journal of Applied Physics
American Institute of Physics
Authors (6)
Miguel Huerga Represa
Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,
Antonio Rodríguez Alhambra
Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,
Melisa del Barrio
Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid 3 , Ciudad Universitaria s/n, 28040 Madrid,
Elena Benito-Peña
Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Plaza Ciencias 2, 28040 Madrid, Spain
Teona Mirea
Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,
Carlos Angulo Barrios
Department of Photonics and Bioengineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 2 , Ciudad Universitaria s/n, 28040 Madrid,