Micrometer-sized integrated plasmonic–electroacoustic hybrid transducer for biosensing applications

M Miguel Huerga Represa (Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,) A Antonio Rodríguez Alhambra (Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,) M Melisa del Barrio (Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid 3 , Ciudad Universitaria s/n, 28040 Madrid,) E Elena Benito-Peña (Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Plaza Ciencias 2, 28040 Madrid, Spain) T Teona Mirea (Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,) C Carlos Angulo Barrios (Department of Photonics and Bioengineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 2 , Ciudad Universitaria s/n, 28040 Madrid,)

Abstract

This paper presents the development of an on-chip, micrometer-sized, dual-mode transducing device for biosensing applications. The device integrates two distinct transducing mechanisms: plasmonic transduction based on Au nanoparticles and electro-acoustic transduction based on a film bulk acoustic resonator (FBAR). The device has been fabricated by synthesizing Au nanoislands via thermal dewetting on the top electrode of an AlN-based solidly mounted resonator–FBAR on a Si substrate. The fabrication of the hybrid device employs microelectro-mechanical systems (MEMS)-compatible processes that have been optimized to ensure both structural integrity and optimal electrical and optical responses. The device's ability to detect protein films through electro-acoustic and plasmonic transduction mechanisms is demonstrated by measuring spectral shifts of the electro-acoustic and optical resonances of the device. These shifts are comparable to those of high-performance independent (non-hybrid) optical and electro-acoustic sensors, while offering the benefits of a combined transducing approach, such as the ability to simultaneously measure several independent physical parameters and to provide cross-validation and a reference point. Its compact size and compatibility with MEMS technology make the presented device highly suitable for mass-produced sensor arrays on chips for multiplexed detection in advanced biosensing monitoring.

Article Details

Volume / Issue Vol. 137, Issue 21
Published June 07, 2025
ISSN 0021-8979
Publisher American Institute of Physics

Journal Info

Journal of Applied Physics

American Institute of Physics

ISSN: 0021-8979 Physical Sciences

Authors (6)

M

Miguel Huerga Represa

Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,

A

Antonio Rodríguez Alhambra

Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,

M

Melisa del Barrio

Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid 3 , Ciudad Universitaria s/n, 28040 Madrid,

E

Elena Benito-Peña

Department of Analytical Chemistry, Faculty of Chemistry, Complutense University of Madrid, Plaza Ciencias 2, 28040 Madrid, Spain

T

Teona Mirea

Department of Electronic Engineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 1 , Ciudad Universitaria s/n, 28040 Madrid,

C

Carlos Angulo Barrios

Department of Photonics and Bioengineering, CEMDATIC, ETSI Telecomunicación, Universidad Politécnica de Madrid 2 , Ciudad Universitaria s/n, 28040 Madrid,