Microbiota-derived IPA protects against colitis by regulating intestinal HMGCS2-mediated ketogenesis to facilitate mucosal healing

Y Yanan Zhang S Shuyu Tu X Xian Shao J Jinxin Meng Z Zhuobiao Zhang W Wei Wei X Xuping Jing Z Zhewen Qin J Jianan Wu W Weilv Xu B Bofei Dong (Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine) J Jinsong Gao A Aijuan Qu S Shuxian Chen L Li Zhang P Peng Gong B Bo Shan H Hui Shi S Shu Jeffrey Zhu

Article Details

Volume / Issue Vol. 17, Issue 1
Published February 06, 2026
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (19)

Y

Yanan Zhang

S

Shuyu Tu

X

Xian Shao

J

Jinxin Meng

Z

Zhuobiao Zhang

W

Wei Wei

X

Xuping Jing

Z

Zhewen Qin

J

Jianan Wu

W

Weilv Xu

B

Bofei Dong

Zhejiang Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang Key Laboratory of Frontier Medical Research on Cancer Metabolism, and Institute of Translational Medicine, Zhejiang University School of Medicine

J

Jinsong Gao

A

Aijuan Qu

S

Shuxian Chen

L

Li Zhang

P

Peng Gong

B

Bo Shan

H

Hui Shi

S

Shu Jeffrey Zhu