MetaCAM as an ensemble-based class activation mapping framework improves model explainability

K Kevin Dick E Emily Kaczmarek O Olivier X. Miguel A Alexa C. Bowie R Robin Ducharme A Alysha L. J. Dingwall-Harvey S Steven Hawken (Ottawa Hospital Research Institute, Ottawa) C Christine M. Armour M Mark C. Walker

Abstract

Abstract The need for clear, trustworthy explanations of deep learning model predictions is essential for high-criticality fields, such as medicine and biometric identification. Class Activation Maps (CAMs) are an increasingly popular category of visual explanation methods for Convolutional Neural Networks (CNNs). However, the performance of individual CAMs depends largely on experimental parameters such as the selected image, target class, and model. Here, we propose MetaCAM, an ensemble-based method for combining multiple existing CAM methods based on the consensus of the top- k % most highly activated pixels across component CAMs. We perform experiments to quantifiably determine the optimal combination of 11 CAMs for a given MetaCAM experiment. A new method denoted Cumulative Residual Effect (CRE) is proposed to summarize large-scale ensemble-based experiments. We also present adaptive thresholding and demonstrate how it can be applied to individual CAMs to improve their performance, measured using pixel perturbation method Remove and Debias (ROAD). Lastly, we show that MetaCAM outperforms existing CAMs and refines the most salient regions of images used for model predictions. In a specific example, MetaCAM improved ROAD performance to 0.393 compared to 11 individual CAMs with ranges from -0.101-0.172, demonstrating the importance of combining CAMs through an ensembling method and adaptive thresholding.

Article Details

Volume / Issue Vol. 16, Issue 1
Published March 30, 2026
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (9)

K

Kevin Dick

E

Emily Kaczmarek

O

Olivier X. Miguel

A

Alexa C. Bowie

R

Robin Ducharme

A

Alysha L. J. Dingwall-Harvey

S

Steven Hawken

Ottawa Hospital Research Institute, Ottawa

C

Christine M. Armour

M

Mark C. Walker