Metabolic Osteoimmune Biodegradable Zn–Mn Alloys: High Strength‐Ductility and In Situ Vascular‐Osteogenic Coupling
Abstract
Abstract Driven by the demand for sustainable, safe, and cost‐effective medical materials, design of biodegradable metals increasingly aims to achieve higher strength and biofunctionality with less alloying. This study proposes a high strengthening‐efficiency (high‐SE) design strategy and develops novel Zn‐0.8Mn‐0.1Mg and Zn‐0.8Mn‐0.1Li alloys. With total alloying additions below 1 wt.%, these alloys achieve yield strength of 369–397 MPa, elongation of 42–57%, and remarkable strengthening efficiency (SE) of 6.4–6.8. These SE values represent the highest level among high strength‐ductile Zn alloys (YS > 300 MPa, EL > 40%). Benefiting from the synergistic release of Zn 2+ , Mn 2+ , and Li + /Mg 2+ ions, both the alloys exhibit superior antibacterial activity, cytocompatibility, controlled degradation rates, and in vivo osteogenesis, demonstrating excellent degradation‐osteogenesis coupling effect. Notably, Zn‐0.8Mn‐0.1Mg further enhances osteogenesis by activating the PI3K/Akt/HIF‐1α signaling axis, which coordinates cascades of immunomodulation (e.g., IGF2, P2rx5), anti‐inflammation (e.g., Nfkbia inhibition), and cellular energy metabolism (e.g., Ndufaf3), resulting in a more pronounced osteogenic effect. This work establishes a new paradigm for high‐efficiency alloy design, achieving simultaneous breakthroughs in mechanical and biofunctionality, offering a promising framework for next‐generation Zn‐based orthopedic implants.
Article Details
Authors (14)
Xiang‐Min Li
Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China
Ding‐Ge Liu
Institute of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing 100191 China
Gang Yang
Zhang‐Zhi Shi
Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China
Fang‐Hai Xin
Institute of Materials Intelligent Technology Liaoning Academy of Materials Shenyang 110004 China
Jia‐Yi Wang
Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China
Yi‐Xuan Wang
Key Laboratory of Environmental Remediation and Ecological Health School of Environmental and Biological Engineering Nanjing University of Science and Technology Nanjing Jiangsu China
Kai‐Ping Liu
Institute of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing 100191 China
Yin Pei
Institute of Sports Medicine Beijing Key Laboratory of Sports Injuries Peking University Third Hospital Beijing 100191 China
Shuang‐Shuang Deng
Institute of Materials Intelligent Technology Liaoning Academy of Materials Shenyang 110004 China
Rui‐Jie Liu
School of Sports Medicine Wuhan Sport University Wuhan 430079 China
Hai‐Jun Zhang
Department of Interventional and Vascular Surgery The Tenth People's Hospital of Shanghai Tongji University Shanghai 200072 China
Xin Zhang
Lu‐Ning Wang
Beijing Advanced Innovation Center for Materials Genome Engineering State Key Laboratory for Advanced Metals and Materials School of Materials Science and Engineering University of Science and Technology Beijing Beijing 100083 China