MedNeXt for accurate medical image classification and segmentation: A lightweight transformer-style convolutional neural network

Z Ziqing Xue P Pengpeng Pi Z Ziyi Liu (New Energy Research Institute, School of Environment and Energy) Z Zhaomu Zeng Z Zhiwei Sun (State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, College of Chemistry and Chemical Engineering)

Abstract

Transformer-based deep learning architectures have achieved notable success across various medical image analysis tasks, driven by the global modeling capabilities of the self-attention mechanism. However, Transformer-based methods exhibit significant computational complexity and a large number of parameters, rendering them challenging to apply effectively in practical medical scenarios. Compared with Transformers, large-kernel Convolutional Neural Networks (CNNs) and Multi-Layer Perceptrons (MLPs) offer more efficient inference while retaining global contextual awareness. Therefore, we rethink the role of large-kernel CNNs and MLPs in medical image analysis and leverage them to replace the heavy self-attention operation, to strike a better balance between performance and efficiency. Specifically, we propose backbone models for medical image classification and segmentation, featured by three lightweight modules: Linear Attention Feed Forward Network (FFN) for enhancing lesion features, Spatial Encoding Module for integrating multi-scale lesion information, and Smooth Depth-Wise Convolution (DwConv) FFN for efficient interaction of channel features. Composed solely of lightweight convolutional and MLP operations, our method achieves a better balance between performance and efficiency, validated by the superior performances on five datasets with varying data scales and diseases, with 98.39% on SARS-COV2-CT-Scan, 98.12% on Monkeypox Skin Lesion Dataset, 98.58% on Large COVID-19-CT scan slice, 79.45% on Synapse and 91.28% on ACDC. The low computational cost, high-performance with limited training data, and generalizability to various of medical tasks make the proposed method a promising and practical solution for medical image classification and segmentation.

Article Details

Journal PLoS ONE
Volume / Issue Vol. 21, Issue 1
Published January 05, 2026
Pages e0340108
ISSN 1932-6203
Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (5)

Z

Ziqing Xue

P

Pengpeng Pi

Z

Ziyi Liu

New Energy Research Institute, School of Environment and Energy

Z

Zhaomu Zeng

Z

Zhiwei Sun

State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, College of Chemistry and Chemical Engineering