Mechanistically Guided Functionalization of α,α-Disubstituted Alkenyl Amides Enabled by a Conformationally Flexible Directing Auxiliary

A Al Vicente Riano D. Lisboa (Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States) P Phornphan Yongpanich (Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States) S Shijia Li (Department of Chemistry) R Ruchira Hariharan (Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States) Y Yilin Cao (Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States) Y Yang Gao J John A. Gurak (Chemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States) P Pavel K. Mykhailiuk (Enamine Ltd, Winston Churchill St. 78, 02094 Kyiv, Ukraine) D Donna G. Blackmond (Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States) P Peng Liu K Keary M. Engle (Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States)

Article Details

Volume / Issue Vol. 148, Issue 8
Published March 04, 2026
Pages 8936-8945
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (11)

A

Al Vicente Riano D. Lisboa

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

P

Phornphan Yongpanich

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

S

Shijia Li

Department of Chemistry

R

Ruchira Hariharan

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

Y

Yilin Cao

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

Y

Yang Gao

J

John A. Gurak

Chemical Process Development, Bristol Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

P

Pavel K. Mykhailiuk

Enamine Ltd, Winston Churchill St. 78, 02094 Kyiv, Ukraine

D

Donna G. Blackmond

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States

P

Peng Liu

K

Keary M. Engle

Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States