Mechanistically Defined Epoxide- and Aziridine-2-carboxamide Electrophiles Enable Stereoselective Covalent Ribonucleic Acid Modulation

C Chungen Li X Xueyi Yang (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States) J Jingsong Shan (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States) K Kyle A. Dickerson (Department of Molecular, Cellular and Developmental Biology) N Noah A. Springer (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States) N Nikhil C. Munshi R Robert T. Batey (Department of Molecular, Cellular and Developmental Biology) M Matthew D. Disney (Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States)

Article Details

Volume / Issue Vol. 148, Issue 16
Published April 29, 2026
Pages 16955-16964
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (8)

C

Chungen Li

X

Xueyi Yang

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States

J

Jingsong Shan

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States

K

Kyle A. Dickerson

Department of Molecular, Cellular and Developmental Biology

N

Noah A. Springer

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States

N

Nikhil C. Munshi

R

Robert T. Batey

Department of Molecular, Cellular and Developmental Biology

M

Matthew D. Disney

Department of Chemistry, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, 130 Scripps Way, Jupiter, Florida 33458, United States