Journal of the American Chemical Society

Mechanistic Insights into Chemoselective Reduction of Engineered Cysteine Residues in Antibodies Using Computational Modeling and Rationally Designed Phosphines

M Manish Hudlikar (Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States) J Jingzhou Wang (Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States) X Xingjian Yu (Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States) C Catherine Going (Discovery Biologics and Protein Sciences, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States) M Mehabaw Getahun Derebe (Discovery Biologics and Protein Sciences, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States) M Manman Lu (Analytical Research and Development, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States) M Manoj Charati (Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States)
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Article Details

Volume / Issue Vol. 148, Issue 15
Published April 22, 2026
Pages 15463-15473
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society
ISSN: 0002-7863 Physical Sciences

Authors (7)

M

Manish Hudlikar

Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

J

Jingzhou Wang

Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

X

Xingjian Yu

Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

C

Catherine Going

Discovery Biologics and Protein Sciences, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

M

Mehabaw Getahun Derebe

Discovery Biologics and Protein Sciences, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

M

Manman Lu

Analytical Research and Development, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

M

Manoj Charati

Discovery Chemistry, Merck & Co., Inc., 213 E Grand Ave, South San Francisco, California 94080, United States

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