Mechanistic Elucidation and Stereochemical Consequences of Alternative Binding of Alkenyl Substrates by Engineered Arylmalonate Decarboxylase

E Elske van der Pol (Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria) T Thomas Schlatzer G Gyula Hoffka B Bruno Di Geronimo (School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, Georgia 30318, United States) J Johannes Eder (Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria) A Anna K. Schweiger (Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria) M Marianna Karava (Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria) D Dominik Gross (Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria) R Roland C. Fischer (Institute for Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria) D Daniel Kracher (Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria) R Romas Kazlauskas (Department of Biochemistry, Molecular Biology and Biophysics, and The Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, Minnesota 55108, United States) K Kenji Miyamoto (Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan) S Shina Caroline Lynn Kamerlin R Rolf Breinbauer (Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria) R Robert Kourist (Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria)

Article Details

Volume / Issue Vol. 147, Issue 43
Published October 29, 2025
Pages 39271-39283
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (15)

E

Elske van der Pol

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

T

Thomas Schlatzer

G

Gyula Hoffka

B

Bruno Di Geronimo

School of Chemistry and Biochemistry, Georgia Institute of Technology, 901 Atlantic Drive NW, Atlanta, Georgia 30318, United States

J

Johannes Eder

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

A

Anna K. Schweiger

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

M

Marianna Karava

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

D

Dominik Gross

Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria

R

Roland C. Fischer

Institute for Inorganic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria

D

Daniel Kracher

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria

R

Romas Kazlauskas

Department of Biochemistry, Molecular Biology and Biophysics, and The Biotechnology Institute, University of Minnesota, 1479 Gortner Avenue, Saint Paul, Minnesota 55108, United States

K

Kenji Miyamoto

Department of Biosciences and Informatics, Keio University, 3-14-1 Hiyoshi, Kohoku-ku, Yokohama 223-8522, Japan

S

Shina Caroline Lynn Kamerlin

R

Rolf Breinbauer

Institute of Organic Chemistry, Graz University of Technology, Stremayrgasse 9, 8010 Graz, Austria

R

Robert Kourist

Institute of Molecular Biotechnology, Graz University of Technology, Petersgasse 14, 8010 Graz, Austria