Mechanism‐Driven Bioactive Indazole Frameworks: Photoinitiated Demethylation–Aromatization Synthesis and Biosensing Applications
Abstract
Abstract Indazole frameworks are pivotal in medicinal chemistry and fluorescent conjugate design. Herein, we reported a photochemical strategy enabling efficient N ‐demethylation and aromatic cyclization of N ‐methyl amines via UV‐induced nitroso intermediates, offering an environmentally benign route to structurally diverse 2 H ‐indazole scaffolds. Diverging from conventional methods, this protocol demonstrates exceptional substrate compatibility with various alkyl/aryl amines, facilitating streamlined assembly of functionalized 2 H ‐indazole modules. The methodology has been successfully applied to synthesize modified drugs and tumor‐specific fluorescent probes targeting G‐quadruplexes. Preliminary evaluations of physiological toxicity and cellular fluorescence imaging highlight their biomedical potential, establishing these strategies as potential tools for pharmacological development and bioimaging research.
Article Details
Authors (10)
Yi‐Feng Ou
State Key Laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University Changsha P.R. China
Songhua Chen
State Key laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P.R. China
Qian Lei
Department of Pulmonary and Critical Care Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital
Yang Shen
Beijing National Laboratory for Condensed Matter Physics, Institute of Physics
Niu Tang
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering Hunan University Changsha Hunan 410082 P.R. China
Yongbo Zhou
Shuang‐Feng Yin
College of Materials and Energy Central South University of Forestry and Technology Changsha People's Republic of China
Nobuaki Kambe
State Key laboratory of Chemo and Biosensing College of Chemistry and Chemical Engineering Hunan University Changsha 410082 P.R. China
Lin Yuan
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering
Renhua Qiu
State Key Laboratory of Chemo and Biosensing, College of Chemistry and Chemical Engineering Hunan University Changsha Hunan 410082 P.R. China