Marrying Perona Malik diffusion with Mamba for efficient pediatric echocardiographic left ventricular segmentation

Z Zi Ye T Tianxiang Chen (Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China) F Fangyijie Wang H Hanwei Zhang L Lijun Zhang (Key Laboratory of Functionalized Molecular Solids of Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science)

Abstract

Abstract Segmenting echocardiographic images is a crucial step in assessing heart function, as clinical indicators can be obtained by precisely delineating the left ventricle. The success of subsequent heart analyses depends entirely on the precision of this segmentation. However, echocardiography is characterized by ambiguity and heavy background noise interference, making accurate segmentation more challenging. Present methods lack efficiency and are prone to mistakenly segmenting some background noise areas, such as the left ventricular area, due to noise disturbance. To address these issues, we introduce P-Mamba, which integrates the Mixture of Experts (MoE) concept for efficient pediatric echocardiographic left ventricular segmentation. Specifically, we utilize the recently proposed ViM layers from the vision mamba to enhance our model’s computational and memory efficiency while modeling global dependencies. In the DWT-based (Discrete Wavelet Transform) Perona-Malik Diffusion (PMD) Block, we introduce a block that suppresses noise while preserving the left ventricle’s local shape cues. Consequently, our proposed P-Mamba innovatively combines the PMD’s noise suppression and local feature extraction capabilities with Mamba’s efficient design for global dependency modeling. We conducted segmentation experiments on two pediatric ultrasound datasets and a general ultrasound dataset, namely Echonet-dynamic, and achieved state-of-the-art (SOTA) results. Specifically, on the Pediatric PSAX (8959 images) and Pediatric A4C datasets (6425 images), we achieved Dice scores of 0.922 and 0.906, respectively; on the EchoNet-Dynamic dataset (19882 images), we achieved a Dice score of 0.931. Leveraging the strengths of the P-Mamba block, our model demonstrates superior accuracy and efficiency compared to established models, including vision transformers with quadratic and linear computational complexity.

Article Details

Volume / Issue Vol. 15, Issue 1
Published September 01, 2025
ISSN 2045-2322
Publisher Nature Portfolio

Journal Info

Scientific Reports

Nature Portfolio

ISSN: 2045-2322 Open Access Life Sciences

Authors (5)

Z

Zi Ye

T

Tianxiang Chen

Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong 999077, China

F

Fangyijie Wang

H

Hanwei Zhang

L

Lijun Zhang

Key Laboratory of Functionalized Molecular Solids of Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science