Managing Lattice Strain Enables Irreversible Single‐Crystal‐to‐Single‐Crystal Transformation of Covalent Organic Frameworks

L Lan Xia H Hongfei Ma Z Zhilv Wang (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China) Y Yuyao Li (Materdicine Lab, School of Life Sciences) Z Zeyue Zhang (College of Chemistry and Molecular Engineering) J Jian Li Z Zhipeng Zhou Y Yonghang Yang (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China) Z Ziyuan Zhang (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China) Y Yuexian Hong (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China) R Rui‐Biao Lin (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China) J Jingyun Fang (Institute of Ecology, College of Urban and Environmental Sciences, and State Key Laboratory of Vegetation Structure, Function and Construction, Peking University) J Jie‐Peng Zhang (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China) W Wei Liu J Junliang Sun (College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences) Z Zhikun Zheng (Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China)

Abstract

ABSTRACT Covalent organic frameworks (COFs) typically rely on reversible covalent chemistry to achieve crystallinity, whereas irreversible and rigid linkages are generally required to achieve enhanced robustness and extended π‐conjugation. Single‐crystal‐to‐single‐crystal (SCSC) transformation offers a promising route to access such frameworks; however, irreversible bond reconfiguration imposes permanent mechanical strain that often disrupts lattice order. Here, we demonstrate sulfur‐assisted SCSC transformation of imine‐linked COFs into rigid benzothiazole‐linked frameworks with experimentally resolved atomic structures. Time‐resolved structural analyses uncover two distinct stress‐accommodation pathways‐cooperative lattice adaptation and stress‐driven transient domain reconstruction that enable irreversible bond fusion while preserving long‐range crystallographic order. The resulting single‐crystalline thiazole‐linked COFs exhibit enhanced chemical stability, rigidified pore architectures, and improved optoelectronic performance. This study establishes a mechanistic framework for managing lattice strain during irreversible covalent transformation and provides a general design principle for constructing structurally robust crystalline polymers.

Article Details

Volume / Issue Vol. 65, Issue 28
Published July 06, 2026
ISSN 1433-7851
Publisher Wiley

Journal Info

Angewandte Chemie International Edition

Wiley

ISSN: 1433-7851 Physical Sciences

Authors (16)

L

Lan Xia

H

Hongfei Ma

Z

Zhilv Wang

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China

Y

Yuyao Li

Materdicine Lab, School of Life Sciences

Z

Zeyue Zhang

College of Chemistry and Molecular Engineering

J

Jian Li

Z

Zhipeng Zhou

Y

Yonghang Yang

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China

Z

Ziyuan Zhang

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China

Y

Yuexian Hong

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China

R

Rui‐Biao Lin

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China

J

Jingyun Fang

Institute of Ecology, College of Urban and Environmental Sciences, and State Key Laboratory of Vegetation Structure, Function and Construction, Peking University

J

Jie‐Peng Zhang

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China

W

Wei Liu

J

Junliang Sun

College of Chemistry and Molecular Engineering, Beijing National Laboratory for Molecular Sciences

Z

Zhikun Zheng

Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education GBRCE For Functional Molecular Engineering Guangdong Engineering Technology Research Centre For High‐performance Organic and Polymer Photoelectric Functional Films School of Chemistry IGCME and State Key Laboratory of Optoelectronic Materials and Technologies Sun Yat‐sen University Guangzhou China