Nature Communications

Machine learning-guided evolution of pyrrolysyl-tRNA synthetase for improved incorporation efficiency of diverse noncanonical amino acids

Q Qunfeng Zhang (State Key Laboratory of Green Chemical Synthesis and Conversion, College of Chemical Engineering) L Ling Jiang (Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China) Y Yadan Niu Y Yujie Li (Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry) W Wanyi Chen J Jingxi Cheng H Haote Ding B Binbin Chen (School of Engineering, Westlake University, Hangzhou, China.) K Ke Liu J Jiawen Cao (Beijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing 100871, P.R. China) J Junli Wang S Shilin Ye L Lirong Yang J Jianping Wu G Gang Xu J Jianping Lin H Haoran Yu (Nanjing University , , ,)
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Article Details

Volume / Issue Vol. 16, Issue 1
Published July 19, 2025
ISSN 2041-1723
Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio
ISSN: 2041-1723 Open Access Life Sciences

Authors (17)

Q

Qunfeng Zhang

State Key Laboratory of Green Chemical Synthesis and Conversion, College of Chemical Engineering

L

Ling Jiang

Optogenetics & Synthetic Biology Interdisciplinary Research Center, Shanghai Frontiers Science Center of Optogenetic Techniques for Cell Metabolism, School of Pharmacy, East China University of Science and Technology, 130 Mei Long Road, Shanghai 200237, China

Y

Yadan Niu

Y

Yujie Li

Engineering Research Center of Advanced Rare Earth Materials (Ministry of Education), Department of Chemistry

W

Wanyi Chen

J

Jingxi Cheng

H

Haote Ding

B

Binbin Chen

School of Engineering, Westlake University, Hangzhou, China.

K

Ke Liu

J

Jiawen Cao

Beijing National Laboratory for Molecular Sciences, National Biomedical Imaging Center, College of Chemistry and Molecular Engineering, Peking University, 292 Chengfu Road, Haidian District, Beijing 100871, P.R. China

J

Junli Wang

S

Shilin Ye

L

Lirong Yang

J

Jianping Wu

G

Gang Xu

J

Jianping Lin

H

Haoran Yu

Nanjing University , , ,

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