Machine-Learning-Guided Discovery of Cytochrome P450 Enzymes for Bioproduction of Jolkinolides and Other Labdane-Related Diterpenoids

K Kaizhou Lu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products) R Rui Zhang K Ke Gao (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products) N Ni Li Z Zihan Cai (Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences) J Jianxun Zhu (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products) J Jiachen Zi (State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products)

Article Details

Volume / Issue Vol. 148, Issue 18
Published May 13, 2026
Pages 19369-19380
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (7)

K

Kaizhou Lu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products

R

Rui Zhang

K

Ke Gao

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products

N

Ni Li

Z

Zihan Cai

Key Laboratory of Biomedical Polymers-Ministry of Education, College of Chemistry and Molecular Sciences

J

Jianxun Zhu

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products

J

Jiachen Zi

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, CAMS Key Laboratory of Enzyme and Biocatalysis of Natural Drugs, and NHC Key Laboratory of Biosynthesis of Natural Products