Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

Ran Chen; Bin Liu; Dawid Jaślan; Lucija Kucej; Veronika Kudrina; Belinda Warnke; Yvonne E. Klingl; Arnas Petrauskas; Sandra Prat Castro; Kenji Maeda; Christian Grimm; Marja Jäättelä

doi:10.1038/s41467-025-60349-5

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

R Ran Chen (Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences) B Bin Liu D Dawid Jaślan L Lucija Kucej V Veronika Kudrina B Belinda Warnke Y Yvonne E. Klingl A Arnas Petrauskas S Sandra Prat Castro K Kenji Maeda C Christian Grimm (Walther Straub Institute of Pharmacology and Toxicology, Endolysosomal Ion Channel Research, Faculty of Medicine, Ludwig-Maximilians-Universität) M Marja Jäättelä

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published June 05, 2025

DOI 10.1038/s41467-025-60349-5

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (12)

R

Ran Chen

Shanghai Frontiers Science Center of Drug Target Identification and Delivery, Shanghai Key Laboratory for Antibody-Drug Conjugates with Innovative Target, State Key Laboratory of Innovative Immunotherapy, School of Pharmaceutical Sciences

B

Bin Liu

D

Dawid Jaślan

L

Lucija Kucej

V

Veronika Kudrina

B

Belinda Warnke

Y

Yvonne E. Klingl

A

Arnas Petrauskas

S

Sandra Prat Castro

K

Kenji Maeda

C

Christian Grimm

Walther Straub Institute of Pharmacology and Toxicology, Endolysosomal Ion Channel Research, Faculty of Medicine, Ludwig-Maximilians-Universität

M

Marja Jäättelä

Lysosomal TMEM165 controls cellular ion homeostasis and survival by mediating lysosomal Ca2+ import and H+ efflux

Article Details

Journal Info

Authors (12)

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