Lung infection in orally inoculated SARS-CoV-2 hamsters

Evelyne Picard-Meyer; Marine Wasniewski; Franck Boué; Edgar Torres-Maravilla; Vinciane Saint-Criq; Thibaut Larcher; Kevyn Beissat; Elsa Jacouton; Sophie Holowacz; Anne-Judith Waligora-Dupriet; Philippe Langella; Alexandre Servat; Elodie Monchatre-Leroy

doi:10.1371/journal.pone.0337915

Lung infection in orally inoculated SARS-CoV-2 hamsters

E Evelyne Picard-Meyer M Marine Wasniewski F Franck Boué E Edgar Torres-Maravilla V Vinciane Saint-Criq T Thibaut Larcher K Kevyn Beissat E Elsa Jacouton S Sophie Holowacz A Anne-Judith Waligora-Dupriet P Philippe Langella A Alexandre Servat E Elodie Monchatre-Leroy

Abstract

The digestive tropism of SARS-CoV-2 due to the presence of the same ACE2 receptor in the digestive system as in the respiratory system raised the question of the role of fecal-oral transmission in the pandemic. The aim of this study was to explore oral infection in hamsters model. SARS-CoV-2 inoculation via the oral and intranasal routes resulted in comparable infection in hamsters. In addition to implications for human health, oral infection could have implications for potential animal reservoirs.

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Article Details

Journal PLoS ONE

Volume / Issue Vol. 20, Issue 12

Published December 04, 2025

Pages e0337915

DOI 10.1371/journal.pone.0337915

ISSN 1932-6203

Publisher Public Library of Science

Journal Info

PLoS ONE

Public Library of Science

ISSN: 1932-6203 Open Access Health Sciences

Authors (13)

E

Evelyne Picard-Meyer

M

Marine Wasniewski

F

Franck Boué

E

Edgar Torres-Maravilla

V

Vinciane Saint-Criq

T

Thibaut Larcher

K

Kevyn Beissat

E

Elsa Jacouton

S

Sophie Holowacz

A

Anne-Judith Waligora-Dupriet

P

Philippe Langella

A

Alexandre Servat

E

Elodie Monchatre-Leroy

Lung infection in orally inoculated SARS-CoV-2 hamsters

Abstract

Article Details

Journal Info

Authors (13)

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