Local Ionic Conditions Modulate the Aggregation Propensity and Influence the Structural Polymorphism of α-Synuclein

M Maria Zacharopoulou (Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.) N Neeleema Seetaloo (Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, U.K.) J James Ross A Amberley D. Stephens (Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.) G Giuliana Fusco (Department of Chemistry) T Thomas M. McCoy (Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.) W Wenyue Dai (Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.) I Ioanna Mela (Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.) A Ana Fernandez-Villegas (Department of Chemical Engineering and Biotechnology) A Anne Martel (Institut Laue Langevin, 71 Avenue des Martyrs, Grenoble CS 20156 38042, France) A Alexander F. Routh (Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.) A Alfonso De Simone (Department of Pharmacy) J Jonathan J. Phillips (Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, U.K.) G Gabriele S. Kaminski Schierle (Department of Chemical Engineering and Biotechnology)

Article Details

Volume / Issue Vol. 147, Issue 16
Published April 23, 2025
Pages 13131-13145
ISSN 0002-7863
Publisher American Chemical Society

Journal Info

Journal of the American Chemical Society

American Chemical Society

ISSN: 0002-7863 Physical Sciences

Authors (14)

M

Maria Zacharopoulou

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

N

Neeleema Seetaloo

Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, U.K.

J

James Ross

A

Amberley D. Stephens

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

G

Giuliana Fusco

Department of Chemistry

T

Thomas M. McCoy

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

W

Wenyue Dai

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

I

Ioanna Mela

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

A

Ana Fernandez-Villegas

Department of Chemical Engineering and Biotechnology

A

Anne Martel

Institut Laue Langevin, 71 Avenue des Martyrs, Grenoble CS 20156 38042, France

A

Alexander F. Routh

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K.

A

Alfonso De Simone

Department of Pharmacy

J

Jonathan J. Phillips

Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, U.K.

G

Gabriele S. Kaminski Schierle

Department of Chemical Engineering and Biotechnology